Director, Translational Medicine Clinical Lead-Immunology

About the Role

We are searching for a Director, Translational Medicine Clinical Lead within the Translational Science & Medicine (TSM) function to be located in Spring House, PA, La Jolla, CA, or Cambridge, MA. The Director, Translational Medicine (TM), will serve as a program and experimental medicine leader in the Immunology TSM function, decisively contributing to accelerating the Immunology pipeline from portfolio entry to Proof-of-Concept (PoC).

This role will function as a clinical lead/study responsible physician on early development programs and trials, contributing to translational plans aligned with overall therapeutic area (TA) strategy and relevant disease area and/or pathway strategies. The Director will lead a cross-functional clinical trial team to deliver major execution milestones within governance-approved timelines and budget commitments, overseeing clinical trials from protocol design through analysis, interpretation, and communication of results.

This position plays a ‘dual role,’ contributing both scientific and clinical development expertise to TSM projects, partnering with Translational Sciences, and engaging deeply with investigators and external experts. The Director will be part of a Translational Medicine Program Lead group responsible for creating and implementing innovative translational plans for portfolio assets.

About Innovative Medicine & Immunology

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries on our team work to develop treatments, find cures, and pioneer the path from lab to life while championing patients every step of the way. Our Immunology team leads the development of transformational medicines for immunological disorders, aiming to restore health to millions living with immune diseases.

Responsibilities

• Design and execute program translational strategies integrating both disease and pathway approaches.
• Design and execute early clinical trials through PoC, including experimental medicine studies.
• Lead a cross-functional trial team to deliver on study milestones and commitments.
• Collaborate with translational science on the development and implementation of clinical biomarker and patient segmentation strategies.
• Support experimental medicine studies and Business Development, including due diligence activities.
• Represent TM on early development teams and in project/portfolio/governance meetings.
• Lead or participate in cross-functional working groups such as scientific and safety review boards.
• Identify and collaborate with academic translational sites to optimize translational strategy and plans.
• Prepare and/or direct the preparation and review of protocols, clinical study reports, translational plans, IBs, INDs, abstracts, manuscripts, and technical reports.
• Present results and updates at department, project, corporate, and scientific meetings.

Qualifications

• MD or MD/PhD degree required.
• Minimum of 3 years of industry and/or translational research experience required.
• Demonstrated supervisory and/or leadership experience with clinical and/or research teams is required.
• Training in Immunology and early clinical development trials is strongly preferred.
• Experience with innovative immune cell-based or biologic therapies is preferred.
• Strong track record in publications is preferred.
• Willingness and ability to travel, including trans-Atlantic travel (up to ~10%) is required.

Locations: Spring House, PA; Cambridge, MA; or La Jolla, CA.

Benefits

• Eligibility to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
• Eligibility to participate in the Company’s long-term incentive program.
• Time off benefits (subject to policy terms and date of hire):
  • Vacation – 120 hours per calendar year
  • Sick time – 40 hours per calendar year (48 hours for Colorado residents; 56 hours for Washington residents)
  • Holiday pay, including Floating Holidays – 13 days per calendar year
  • Work, Personal and Family Time – up to 40 hours per calendar year
  • Parental Leave – 480 hours within one year of birth/adoption/foster care
  • Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
  • Caregiver Leave – 80 hours in a 52-week rolling period
  • Volunteer Leave – 32 hours per calendar year
  • Military Spouse Time-Off – 80 hours per calendar year

Pay

The anticipated base pay range for this position is $199,000 - $343,850.