Director, Translational Immunology

Responsibilities

• Serve as the immunology lead supporting a late-stage clinical development program.
• Contribute to the development and execution of nonclinical and translational strategies aligned with program team objectives.
• Partner with cross-functional teams to support program governance, development planning, and scientific decision-making.
• Assess emerging scientific, clinical, and competitive developments relevant to assigned program and associated strategy.
• Contribute to the identification and evaluation of new therapeutic opportunities in rare disease for the assigned program that may provide clinical benefit.
• Develop translational strategies linking mechanism of action, target engagement, pharmacodynamic activity, and clinical outcomes.
• Support identification and implementation of mechanistic, pharmacodynamic, predictive, and response biomarkers.
• Collaborate with cross-functional teams to support implementation of biomarker strategies and data interpretation throughout development.
• Contribute to scientific publications, presentations, and external communications.
• Collaborate with Regulatory and nonclinical colleagues to support regulatory submissions and health authority interactions.
• Interpret pharmacology, toxicology, and translational data in the context of clinical development and regulatory objectives.
• Support preparation and review of investigator brochures, briefing documents, regulatory submissions, and other development-related documents.
• Ensure research and translational activities are aligned with development plans and regulatory expectations.
• Lead scientific interactions with CROs, academic collaborators, consultants, and key opinion leaders.
• Design, oversee, and contribute to interpretation of externally conducted translational and mechanistic nonclinical studies.
• Represent Travere at scientific meetings, conferences, and external collaborations.
• Identify and build productive scientific relationships that advance understanding of disease biology and therapeutic mechanisms.
• Contribute to building immunology and translational science capabilities within the Research and Nonclinical Development organization.
• Mentor colleagues and provide scientific leadership across programs and functions.
• Foster a culture of scientific excellence, collaboration, innovation, and continuous learning.
• Demonstrate the potential and desire to assume increasing scientific leadership responsibilities as the organization grows.
• Provide deep scientific expertise in B-cell biology, adaptive immunity, and innate immune signaling.
• Evaluate disease mechanisms and therapeutic opportunities in immune-mediated and rare diseases.
• Integrate mechanistic biology, translational science, and clinical observations to inform development strategies.
• Serve as an internal subject matter expert in immunology and immune-mediated disease biology.
• Maintain awareness of advances in disease biology, therapeutic targets, and emerging technologies relevant to immunology and translational medicine.

Requirements

• Bachelor’s Degree in Life Science or other related discipline required.
• PhD, MD, PharmD, or equivalent advanced degree in Immunology, Cell Biology, Molecular Biology, Pharmacology, or a related scientific discipline preferred.
• Minimum 10 years of relevant experience in the biopharmaceutical industry required; or 6 years with PhD, MD, PharmD, or equivalent.
• Demonstrated expertise in immunology, with strong knowledge of B-cell biology and immune signaling pathways.
• Experience supporting clinical-stage drug development programs.
• Experience translating mechanistic biology into development strategies and clinical applications.
• Experience leading externally conducted research through CROs, academic collaborators, and consultants.
• Working knowledge of regulatory requirements and expectations for nonclinical support of clinical development programs.
• Experience contributing to regulatory submissions, investigator brochures, briefing documents, or related development activities.
• Demonstrated ability to work effectively in cross-functional, matrixed organizations.
• Prior experience leading scientific initiatives, projects, or multidisciplinary teams.
• Excellent communication, presentation, and influencing skills.
• Scientific curiosity, intellectual rigor, and commitment to improving outcomes for patients with serious diseases.
• Ability to thrive in a collaborative, fast-paced, virtual biotechnology environment.