Jobs · Healthcare · Massachusetts

Senior Director, Immunology and Translation

BioSpace · Waltham, MA · 1 mo ago
HybridHealthcare$302k–$350k/yrFull-time

Responsibilities

  • Serve as the primary scientific expert and internal champion for one or more immunology disease areas, including but not limited to rheumatology, neuroimmunology, and rare dermatology
  • Translate deep mechanistic understanding of immune pathology into actionable therapeutic hypotheses and target identification strategies
  • Maintain a current and comprehensive view of the competitive landscape, emerging science, and unmet medical need across assigned disease areas
  • Represent CSL Behring at key scientific conferences, advisory boards, and KOL meetings; build and leverage a broad external network of thought leaders, clinical investigators, and academic collaborators
  • Drive end-to-end asset progression from ideation through first-in-disease designation, integrating scientific rationale, translational endpoints, patient population selection, and regulatory strategy
  • Lead or co-lead target and asset evaluation activities including preclinical data package reviews, mechanism-of-action assessments, and translational feasibility analyses
  • Provide scientific input to IND-enabling studies, proof-of-concept study designs, and Phase 1/1b protocol development
  • Collaborate with the discovery and translational teams to define disease-relevant biomarkers, pharmacodynamic readouts, and patient stratification strategies for early clinical programs
  • Actively contribute to R&D programs as a subject matter expert and provide guidance for the clinical development pathway
  • Collaborate with Research Therapeutic Area Lead, RPLs, and Immunology core team members to develop and maintain a best-in-class immunology portfolio
  • Partner with Business Development to assess in-licensing, partnering, and acquisition opportunities within the immunology space, providing scientific due diligence leadership
  • Contribute to Target Product Profiles (TPPs), integrated development plans, and portfolio reviews
  • Provide disease area expertise to regulatory submissions, clinical study reports, and scientific communications
  • Work collaboratively with Medical Affairs, Clinical Operations, and translational colleagues to align development strategies

Qualifications

  • MD, DO, or PhD in Immunology, or a closely related discipline
  • 12+ years of experience in drug development within a biotech, pharmaceutical, or academic environment
  • Demonstrated experience in preclinical to first-in-disease (or equivalent early clinical milestone) in immunology
  • Deep scientific expertise in the immunological mechanisms underpinning autoimmune and inflammatory diseases
  • Established and active network in drug development with recognized relationships across rheumatology, neuroimmunology, and/or dermatology communities
  • Proven track record in evaluating preclinical and clinical assets, including target assessment, data package review, and go/no-go decision-making
  • Strong ability to synthesize complex scientific data and communicate strategy clearly to diverse audiences including senior leadership

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