Director Supply Chain Planning

Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. Beam’s suite of gene editing technologies is anchored by base editing, enabling precise, predictable, and efficient single base changes at targeted genomic sequences without making double-stranded breaks in the DNA. This has the potential to enable a wide range of therapeutic editing strategies across a diversified portfolio of programs.

About the role

The Global Supply Chain Planning & Network Strategy leader will be responsible for supply and raw material planning, supply network design and optimization, inventory ownership, and ensuring a strong supply plan handoff to internal and external partners. This role will ensure uninterrupted supply of clinical and future commercial products via Beam’s Clinical S&OP process. The position reports to the VP of Supply Chain and partners with leadership in TechOps, ClinOps, Finance, CMC, and Program Teams to lead short-term integrated production and raw materials planning as well as long-range strategic supply chain planning. The role will also partner with Patient Supply, Commercial, CMC, Engineering, and PD for commercial supply chain design and capabilities of late-stage clinical development programs.

This role will design and implement core capabilities driving proactive modeling and decision analysis of supply network and product strategy, including governance, S&OP business processes, and supporting technology. It will develop and execute a global inventory management program to ensure raw and critical material availability at Beam’s North Carolina manufacturing site and CDMO sites. The role will enhance site planning and scheduling capabilities at Beam’s Durham, NC manufacturing site and partner with the SAP business lead to advance technology capabilities.

Responsibilities

• Develop and implement supply chain analytics, planning, and resilience processes and policy across the global supply chain for all stages of the product lifecycle.
• Oversee and manage global end-to-end supply planning and network design as Beam transitions from clinical to commercial stage over the next few years.
• Ensure appropriate inventory, including design/policy for Raw and Critical Materials (pDNA, mRNA, gRNA, mAb, lipids), Drug Substance, Bulk Drug Product, and Finished Drug Product.
• Oversee and manage the S&OP process. Collaborate cross-functionally with ClinOps and Program teams to ensure accurate demand forecasts and scenarios/analytics.
• Responsible for supply network analysis to support tactical and strategic decision-making.
• Coordinate with Finance, Program Teams, CMC, and PD to ensure robust modeling of product and network scenarios to support decision-making in governance forums.
• Perform risk-based review of the supply chain to determine appropriate inventory levels. Communicate demand uncertainties or risks and develop options for optimizing supply network capacity and capabilities.
• Deliver a response plan for disruptive challenges.
• Ensure that the plan and capabilities of each CDMO and suppliers are adapted to minimize the risk of disruption and deliver an effective response to ensure resilience.
• Ensure optimal economics and adequate supply chain security in partnership with Finance for Budget, LRP, and capital planning processes.
• Oversee the team to develop supply chain strategies, bringing integrated solutions to the production network. Hire, develop, and mentor staff as needed.
• Direct activities of all functions involved in planning, warehousing, and logistics to ensure control of materials from receipt of raw materials to delivery of the finished product, including inventory controls.
• Oversee and publish metrics to reflect the effectiveness and efficiency of department activities, including supply chain KPIs on inventory, responsiveness, and costs. Implement KPIs that drive accountability and improvement in both operational and financial metrics.
• Partner with NC Manufacturing to implement standardized site planning and scheduling processes and procedures.
• Participate in the design and implementation of SAP Phase 3 and IT roadmap in preparation for commercial launch.
• Other duties as assigned.

Qualifications

• BS/BA degree in Business, Science, Engineering, or related field with 15+ years of experience in global supply chain from pharma, biotech, or cell & gene therapy companies.
• Prior drug development, manufacturing, or clinical operations experience is a plus.
• Master’s degree or MBA preferred.
• Prior management skills with leadership experience building and sustaining global teams.
• Passion for patients, collaborative and effective leader.
• Advanced knowledge of contracts, negotiation, and vendor management.
• Knowledge of practical implications of Sarbanes-Oxley controls.
• Knowledge of continuous improvement methodologies and tools.
• Strong organizational and facilitation skills, with a high degree of customer focus.
• Focuses on immediate and urgent business needs while driving long-term strategic plans and capability & organizational development.
• Provides strategy, vision, and direction regarding issues that may have company-wide impact.
• Requires in-depth knowledge of the functional area, business strategies, and the company’s goals. Possesses industry-leading knowledge of sourcing direct materials.
• Expertise and track record in manufacturing and supply chain execution and oversight.
• Expert in standing up a formal S&OP process. Extensive experience in supply chain planning, SAP ERP system, capacity modeling, supply network strategy, and optimization.
• Expertise and proven track record in supply chain risk management.
• Possesses in-depth knowledge of industry and system best practices.
• Solid knowledge of regulatory requirements, regulatory guidances, including pharmaceutical GMPs and ICH guidance.
• Current on biopharma supply chain, manufacturing technologies, supplier network, CMO network, performance, and capacity.
• Possesses understanding and application of principles, concepts, practices, and standards for DS and DP manufacturing in the biopharma industry.
• Strong communication, negotiation, and interpersonal skills.
• Strong analytical skills and ability to clearly communicate at tactical and strategic levels with teams and senior management.
• Ability to work in a dynamic and challenging environment.
• Some travel may be required.
• Must be able to work onsite; this is not a remote role.