Director, New Target Strategy

Responsibilities

• Lead identification and prioritization of novel therapeutic targets using information such as human genetics, functional genomics, emerging disease biology and clinical data.
• Contribute to portfolio strategy by evaluating disease mechanisms, competitive landscapes, and unmet medical needs and drive hypothesis generation grounded in human disease relevance and translational potential.
• Serve as a scientific lead for internal and external diligence activities related to new targets, platforms, non-clinical- and early clinical-stage assets, critically assess biological plausibility, differentiation, feasibility, and risk of potential targets and programs and prepare and present clear, data driven recommendations to senior business development and research leadership.
• Design target validation strategies incorporating in vitro, in vivo, and ex vivo approaches ensuring development of high-quality biological data packages to support progression into lead candidate development, collaborating closely with chemistry, biologics, and platform teams to align biology with modality and development strategy.

Qualifications and Experience

• Ph.D. in Immunology, Biology, Pharmacology, or a related life sciences discipline with 10+ years of discovery research experience in biotech or pharmaceutical industry, including demonstrated leadership at the program or project level.
• Proven track record in target identification and validation within immunology, cardiovascular disease, or related complex disease areas with demonstrated ability to translate human biology into actionable discovery hypotheses.
• Experience leading or contributing to scientific diligence activities for internal pipeline programs and external opportunities.
• Strong background in target biology, mechanism of action, and preclinical disease models, experience integrating multi-omic, genetic, translational, and pharmacology data and the ability to assess strengths, gaps, and risks in early discovery programs.

Pay

$215,000 - $250,000 USD

Benefits

N/A

Schedule

Based in Lexington, MA and requires employees to be onsite five days per week.