Director, Immunoassay-based Biomarker Discovery and Analysis - Neuroscience

About the role

Design, development, and validation of novel immunoassay-based biomarker methods, as well as applications of these methods for early- and late-phase clinical trials in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, ALS, and rare brain disorders.

Work with project team leads, including Dr. Kaj Blennow (Vice President of Neuroscience Biomarker Development), and other associates to perform experiments to support both the preclinical and clinical characterization and evaluation of therapeutic molecules through biomarker assay development.

Assist with the planning and execution of immunoassay method developments, method optimization and validation, as well as sample analyses from cohorts, working with both internal and external partners in complex studies. Work directly on-site with methods in the laboratory, and with summarizing and reporting method status and results for internal partners.

Implement assay validation procedures to deliver high-performance biomarker assays for preclinical and clinical sample analyses. Collaborate cross-functionally with internal stakeholders (medical, operations, statistics, regulatory) and external partners (CROs, academic institutions) to ensure biomarker validation and successful integration into clinical programs.

Qualifications

• Master’s and/or PhD in Neuroscience, Biochemistry, or a related scientific field, with 0-5+ years of industry, academic, or postdoctoral experience in biomarker development, with recognized expertise in immunoassay-based methods for brain diseases.

Skills

• Understanding of the principles for antibodies and other affinity-based molecules, immunoassay design, and protein biomarker quantification, as well as documented hands-on experience in immunoassay development and validation for biomarker applications in clinical diagnostics, clinical trials, or preclinical sample analysis.
• Technical skills in qualitative (e.g., electrophoresis techniques, Western blot) and quantitative (e.g., ELISA, MSD, Ella, Simoa) immunoassay-based analyses.
• Proven leadership in managing and mentoring biomarker research teams in academic or industry settings.
• Experience in ultrasensitive technologies (e.g., NuLISA) and protein separation and purification techniques (e.g., HPLC, immunoprecipitation) is a plus.
• Excellent communication and collaboration skills, with the ability to present and influence both internal and external stakeholders.

Benefits

• Eligibility to participate in a company-sponsored 401(k) and pension plan.
• Vacation benefits.
• Medical, dental, vision, and prescription drug benefits.
• Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts).
• Life insurance and death benefits.
• Certain time off and leave of absence benefits.
• Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).
• Company bonus (depending, in part, on company and individual performance).

Pay

The anticipated wage for this position is $153,000 - $281,600.