Director, High-Throughput Biology

About the role

The Director, High-Throughput Biology (HTB) is responsible for the strategy, performance, and evolution of Eikon’s high-throughput screening and discovery platforms. This role leads end-to-end high-throughput screening execution across automated and imaging-based platform technologies, ensuring delivery of scalable, reproducible, decision-enabling data that supports portfolio priorities. Operating at the intersection of biology, automation engineering, and computational science, this leader establishes standards for assay robustness, data quality, platform reliability, and technical execution, while building a high-performing organization capable of advancing discovery programs efficiently and at scale.

Qualifications

• PhD in Biological Sciences, Computational Sciences, or a related discipline with 10+ years of experience in high-throughput or high-content screening environments.
• Demonstrated expertise with automated screening platforms, including 384- and/or 1536-well formats.
• Experience screening compound libraries larger than 100k.
• Experience advancing drug discovery programs from hit identification through lead optimization.
• Experience with microscopy-based or imaging-enabled screening platforms.
• Experience with genetic screens or systems biology approaches.
• Strong expertise in statistical analysis and large-scale dataset quality control, with proficiency in Python.
• Experience building or contributing to scalable data processing pipelines.
• Proficiency with compound databases, LIMS, and enterprise data systems.
• Proven cross-functional leadership across biology, chemistry, engineering, and data teams.
• Experience with single-molecule imaging technology is preferred.
• Experience with novel technologies or assay development for drug discovery is preferred.
• Strong computational science capability and familiarity with machine learning or artificial intelligence applications in phenotypic or multiparametric screening are preferred.
• Demonstrated ability to build hybrid biology and computational teams is preferred.

Benefits

Eikon Therapeutics offers a comprehensive benefits package including:

• 401(k) plan with company matching
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
• Mental health and wellness benefits
• Weeklong summer and winter holiday shutdowns
• Generous paid time off and holiday policies
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
• Enhanced parental leave benefit
• Daily subsidized lunch program when on-site

Pay

The expected salary range for this role is $213,000 to $250,000 depending on skills, competency, and the market demand for your expertise.