Director, Clinical Pharmacology

About the role

The Director, Clinical Pharmacology (CP) at Arcus is responsible for supporting all clinical pharmacology-related activities across small molecule and biotherapeutics in Phase 1-3 of clinical development. They collaborate with CP leadership to design, conduct, analyze, interpret, and communicate results from CP studies, as well as develop short/medium-term plans for projects.

Responsibilities

• Design and execute clinical pharmacology studies
• Design clinical pharmacology portion of other clinical studies
• Perform hands-on analyses of data using noncompartmental methods, population PKPD modeling and simulation, and exposure-response methodologies
• Disseminate risk/benefit implications to CP and project teams
• Develop short/medium-term plans for projects at all stages of clinical development
• Communicate these strategies at internal meetings
• Collaborate and communicate with partner lines at study management team meetings
• Contribute to the preparation of key documents including investigators brochures, clinical study protocols, study reports, and regulatory briefing documents
• Establish best practices for CP activities

Requirements

• An advanced degree in Pharmaceutics/Pharmacy/Engineering/Statistics with demonstrated expertise in quantitative PKPD skills
• Basic understanding of drug development and CP principles
• Expertise with standard modelling and simulation software (NONMEM, S-Plus/R, etc)
• Expertise in other modelling software (e.g. GastroPlus, SimCYP, MATLAB, Berkeley-Madonna, etc.) is highly desirable
• Experience of active and effective communication with cross-functional project teams
• Good oral and written communication skills as shown by a publication track record

Qualifications

• Education: Advanced degree in Pharmaceutics/Pharmacy/Engineering/Statistics
• Experience: Demonstrated expertise in quantitative PKPD skills, experience with modelling and simulation software, and experience with cross-functional project teams

Skills

• Independent worker, self-motivated, and self-starter
• Works under minimal supervision on all activities
• Self-monitors progress, recognizes delays, and communicates appropriately
• Anticipates problems in the execution of CP deliverables, displays problem-solving skills to come up with practical and innovative solutions
• Demonstrates leadership courage through effective conflict navigation and resolution
• Strong oral and written communicator

Benefits

Includes a competitive market-based salary, participation in stock programs, a performance-based bonus, and a comprehensive benefits package. Arcus is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind.

Pay

$245,000 - $260,000 USD annually

Schedule

Primarily a sedentary office classification, with occasional evening and weekend commitments, and occasional travel (~15%) domestically and internationally. Position can be based at Hayward or Brisbane, CA or remote.