Associate Scientist - Therapeutic Proteins

We are seeking a highly motivated, detail-oriented, and dependable Associate Scientist to join our Therapeutic Proteins - Antibody Radioconjugates Technology team. In this role, you will conjugate antibodies with bifunctional chelates and fluorescent probes, and perform radiolabeling to support preclinical immunoPET (iPET) and Cryo-fluorescence Tomography (CFT) imaging. Your work will generate and characterize Zr-89 radiolabeled and fluorescently-conjugated tracers from our portfolio of antibodies and antibody-based therapeutics, enabling quantitative in vivo imaging studies across Oncology, Immuno-Oncology, and other therapeutic focus areas.

Responsibilities

• Performs bioconjugation of antibodies with bifunctional chelating agents (DFO, DOTA, etc.) and fluorescent probes following validated protocols
• Characterizes antibody bioconjugates using SE-HPLC, SDS-PAGE, Western blot, and UV/Vis spectroscopy
• Radiolabels bioconjugated antibodies with Zr-89, Cu-64, or other radionuclide isotopes; purifies radiolabeled products for same-day use in time-critical imaging studies
• Runs quality control testing using radio-HPLC, radio-iTLC, and gamma counting to verify tracer quality before release
• Maintains mammalian cell culture lines and performs cell-based assays to validate tracer binding and function
• Coordinates tracer preparation timelines with imaging scientists and project teams across multiple therapeutic areas
• Maintains detailed electronic laboratory notebooks and radiation safety records in compliance with regulations
• Maintains instruments, troubleshoots instrumental/experimental problems, and orders/maintains supplies

Requirements

• B.S. in Chemistry, Biochemistry, Chemical Engineering, Chemical Biology, or a related field with 1-2 years of laboratory experience
• Comfort working with radioactive materials and willingness to complete radiation safety training
• Hands-on experience with protein chemistry and bioconjugation techniques, or strong foundational knowledge with willingness to learn
• Experience with chromatographic techniques (HPLC, FPLC, or column chromatography) and mammalian cell culture
• Proficiency with computers, data analysis software (Excel, Prism, or similar), and electronic laboratory notebook systems
• Ability to lift 50 lbs

Skills

• Hands-on experience with protein chemistry, bioconjugation, and chromatographic techniques; experience performing radiochemistry is a plus
• Thrive in a collaborative, fast-paced environment where reliability and punctuality directly impact team success
• Take pride in maintaining accurate, complete laboratory records
• Excel at attention to detail and following established protocols with precision
• Self-motivated and eager to work independently after training
• Strong communication skills

Benefits

• Competitive and comprehensive total rewards package which may include annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match
• Health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability)
• Paid time off and family support benefits

Pay

Salary Range (annually): $70,300.00 - $110,100.00

Schedule

This role is on-site in Tarrytown, NY.