Associate Scientist - Therapeutic Proteins - Antibody Radioconjugates Technology

About the role

Join Therapeutic Proteins - Antibody Radioconjugates Technology at Regeneron, where you'll contribute to developing life-changing medicines through innovative research. Specifically, you'll be responsible for bioconjugating antibodies with bifunctional chelates and fluorescent probes, and radiolabeling these conjugates for preclinical imaging studies.

Responsibilities

• Perform bioconjugation of antibodies with bifunctional chelating agents (DFO, DOTA, etc.) and fluorescent probes following validated protocols
• Characterize antibody bioconjugates using SE-HPLC, SDS-PAGE, Western blot, and UV/Vis spectroscopy
• Radiolabel bioconjugated antibodies with Zr-89, Cu-64, or other radionuclide isotopes; purify radiolabeled products for same-day use in time-critical imaging studies
• Run quality control testing using radio-HPLC, radio-iTLC, and gamma counting to verify tracer quality before release
• Maintain mammalian cell culture lines and perform cell-based assays to validate tracer binding and function
• Coordinate tracer preparation timelines with imaging scientists and project teams across multiple therapeutic areas
• Maintain detailed electronic laboratory notebooks and radiation safety records in compliance with regulations
• Coordinate with instrument technicians to maintain instruments, troubleshoot experimental problems, and order/maintain supplies

Requirements

• B.S. in Chemistry, Biochemistry, Chemical Engineering, Chemical Biology, or a related field with 1-2 years of laboratory experience
• Hands-on experience with protein chemistry, bioconjugation, and chromatographic techniques
• Experience with chromatographic techniques (HPLC, FPLC, or column chromatography)
• Strong communication skills

Qualifications

• Self-motivated and eager to work independently after training
• Attention to detail and following established protocols with precision
• Collaborative and thrive in a fast-paced environment

Skills

• Experience performing radiochemistry
• Experience working with radioactive materials
• Strong computer skills, including data analysis software (Excel, Prism, or similar)
• Proficiency with electronic laboratory notebook systems

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include:

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits
• 401(k) company match
• Health and wellness programs
• Fitness centers
• Insurance benefits (medical, dental, vision, life and disability)
• Paid time off
• Family support benefits

Pay

$70,300.00 - $110,100.00 annually

Schedule

On-site