Associate Scientist - Therapeutic Proteins - Antibody Radioconjugates Technology

Regeneron uses science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated, detail-oriented, and dependable Associate Scientist to join our Therapeutic Proteins - Antibody Radioconjugates Technology team. In this role, you will conjugate antibodies with bifunctional chelates and fluorescent probes, and perform radiolabeling to support preclinical immunoPET (iPET) and Cryo-fluorescence Tomography (CFT) imaging.

About the role

You will generate and characterize Zr-89 radiolabeled and fluorescently-conjugated tracers from our portfolio of antibodies and antibody-based therapeutics. Your work will enable quantitative in vivo imaging studies across Oncology, Immuno-Oncology, and other therapeutic focus areas, directly supporting same-day imaging studies that visualize biodistribution, tumor/tissue targeting, and pharmacokinetics of therapeutic candidates in preclinical models.

Responsibilities

• Performs bioconjugation of antibodies with bifunctional chelating agents (DFO, DOTA, etc.) and fluorescent probes following validated protocols
• Characterizes antibody bioconjugates using SE-HPLC, SDS-PAGE, Western blot, and UV/Vis spectroscopy
• Radiolabels bioconjugated antibodies with Zr-89, Cu-64, or other radionuclide isotopes; purifies radiolabeled products for same-day use in time-critical imaging studies
• Runs quality control testing using radio-HPLC, radio-iTLC, and gamma counting to verify tracer quality before release
• Maintains mammalian cell culture lines and performs cell-based assays to validate tracer binding and function
• Coordinates tracer preparation timelines with imaging scientists and project teams across multiple therapeutic areas
• Maintains detailed electronic laboratory notebooks and radiation safety records in compliance with regulations
• Maintains instruments, troubleshoots instrumental/experimental problems, and orders/maintains supplies

Requirements

• B.S. in Chemistry, Biochemistry, Chemical Engineering, Chemical Biology, or a related field with 1-2 years of laboratory experience
• Comfort working with radioactive materials and willingness to complete radiation safety training
• Hands-on experience with protein chemistry and bioconjugation techniques, or strong foundational knowledge with willingness to learn
• Experience with chromatographic techniques (HPLC, FPLC, or column chromatography) and mammalian cell culture
• Proficiency with computers, data analysis software (Excel, Prism, or similar), and electronic laboratory notebook systems
• Ability to lift 50 lbs

Skills

• Hands-on experience with protein chemistry, bioconjugation, and chromatographic techniques; experience performing radiochemistry is a plus
• Thrives in a collaborative, fast-paced environment where reliability and punctuality directly impact team success
• Takes pride in maintaining accurate, complete laboratory records
• Excels at attention to detail and following established protocols with precision
• Self-motivated and eager to work independently after training
• Strong communication skills

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Pay

Salary Range (annually): $70,300.00 - $110,100.00

Schedule

This role is on-site in Tarrytown, NY.