Associate Scientist/Scientist Cell-Based Assays & In Vivo Oncology (Temporary to direct)

About the role

Aragen Bioscience is a leading contract research organization focused on accelerating product development. Aragen's offerings include pre-clinical efficacy studies and cell-based assays as well as antibody discovery, recombinant protein production, and purification and stable cell line development. We offer clients high quality service and superior R&D partnerships.

Essential Functions

• Design, execution, and troubleshooting of cell-based assays
• Day-to-day management of in vivo tumor efficacy studies supporting preclinical oncology programs
• Development, qualification, and routine execution of viability, proliferation, cytotoxicity, ADCC/CDC, reporter, and target-engagement assays
• Maintenance of primary and immortalized cell cultures and cell banks
• ELISA/MSD, Western blot/JESS, flow cytometry, and quantitative PCR
• Inventory and tracking of samples generated by preclinical projects
• Tumor cell preparation and management of xenograft and syngeneic tumor models
• Tumor measurement and body-weight monitoring; dosing by multiple routes (IP, IV, PO, SC)
• Randomization and study scheduling; terminal procedures; tissue and blood collection for downstream analysis
• Maintain accurate study records and support IACUC protocol preparation and amendments
• Work in full compliance with applicable animal welfare regulations
• Troubleshoot assays; perform data analysis and data presentation; manage multiple projects; learn new areas of research
• In vitro and cell-based assay responsibilities will constitute ~80% of effort; in vivo pharmacology 20%

Requirements

• MS or PhD in Biology, Cell Biology, Immunology, Pharmacology, or a related life science discipline
• 3+ years' hands-on experience developing and running cell-based assays within a drug discovery organization or CRO (PhD) or 7+ years (MS)
• Deep knowledge of cell and molecular biology techniques, including sterile technique, and assay troubleshooting and optimization
• Demonstrated experience managing in vivo tumor models, including xenograft and/or syngeneic mouse studies, with proficiency in tumor implantation, caliper measurement, dosing (IP, IV, PO, SC), and terminal procedures
• Working knowledge of IACUC protocol preparation and applicable animal welfare regulations
• Strong data analysis and presentation skills, including dose-response and tumor-growth-inhibition analysis in GraphPad Prism or equivalent, with accurate record keeping
• Ability to work in an environment of teamwork and collaboration
• Excellent communication and interpersonal skills and proven success working in matrix environments

Benefits

Aragen Bioscience provides a stimulating work environment in which talented employees expand their technical skills and scientific knowledge and contribute directly to the ongoing success of the organization. We are located in Morgan Hill, California, at the south end of the Silicon Valley.

Pay

$80,000 to $110,000 depending on experience