IN VIVO RESEARCH ASSOCIATE, ONCOLOGY

About The Role

You will perform in vivo studies of our AAV-based cancer therapeutic candidates to advance our oncology pipeline and technology platform. You will contribute to the design of the preclinical studies and their execution, ensuring high level of scientific rigor and compliance with relevant regulations. This is an ideal position for a candidate with a strong background in vivo experiments who thrives in a team-oriented, cross-disciplinary, and collaborative environment.

Responsibilities

• Plan and execute in vivo studies in collaboration with discovery and data scientists
• Perform various in vivo procedures in mice: dosing via IV, IP and SC, blood sampling, and complex surgeries to establish orthotopic tumor models via abdominal surgery
• Conduct routine animal health monitoring and recording and monitor tumor volume by in vivo imaging or caliper measurement
• Perform necropsy, biological sample processing (e.g. FFPE and OCT), tissue dissociation and cell sorting via MACS or FACS, and downstream analysis e.g. flow cytometry and immune assays
• Conduct mammalian cell culture and QC for in vivo experiments
• Generate, document and analyze in vivo study data in accordance with study protocols, SOPs, and regulatory guidelines
• Interface with external laboratories and partners

Qualifications

• MSc in life sciences
• At least 3 years of hands-on experience working with murine oncology models in an academic or industry setting
• Strong hands-on experience with complex rodent procedures, such as thoracic or abdominal surgery, suturing and wound closure, and tail vein dosing
• Experience in necropsy, tissue handling and processing, tumor cell and splenocyte isolation, and flow cytometry
• Detail-oriented with strong organizational and record-keeping skills
• Excellent communication skills and ability to collaborate effectively in a cross-functional team

Preferred Skills

• Experience working in a GLP or regulatory-compliant environment is a plus
• Experience with larger mammals is a plus but not required
• Experience with external vendors is a plus but not required
• Any experience with regulatory filings is a plus