Associate Scientist/Scientist Cell-Based Assays & In Vivo Oncology (Temporary to direct)

About the role

Aragen Bioscience is a leading contract research organization focused on accelerating product development. We offer clients high-quality service and superior R&D partnerships in pre-clinical efficacy studies, cell-based assays, antibody discovery, recombinant protein production, purification, and stable cell line development.

This position is temporary with the potential to transition to a direct hire. The successful candidate will work under the direction of a director, with approximately 80% effort dedicated to in vitro and cell-based assay responsibilities and 20% to in vivo pharmacology.

Responsibilities

• Design, execute, and troubleshoot cell-based assays, including viability, proliferation, cytotoxicity, ADCC/CDC, reporter, and target-engagement assays.
• Maintain primary and immortalized cell cultures and cell banks.
• Perform ELISA/MSD, Western blot/JESS, flow cytometry, and quantitative PCR.
• Manage inventory and tracking of samples generated by preclinical projects.
• Prepare and manage xenograft and syngeneic tumor models, including tumor cell preparation, tumor measurement, body-weight monitoring, dosing (IP, IV, PO, SC), randomization, study scheduling, terminal procedures, and tissue/blood collection.
• Maintain accurate study records and support IACUC protocol preparation and amendments in compliance with animal welfare regulations.
• Analyze and present data, including dose-response and tumor-growth-inhibition analysis using GraphPad Prism or equivalent.
• Troubleshoot assays and manage multiple projects while demonstrating an interest in learning new research areas.

Requirements

• MS or PhD in Biology, Cell Biology, Immunology, Pharmacology, or a related life science discipline.
• 3+ years' hands-on experience developing and running cell-based assays within a drug discovery organization or CRO (PhD) or 7+ years (MS).
• Deep knowledge of cell and molecular biology techniques, including sterile technique, assay troubleshooting, and optimization.
• Demonstrated experience managing in vivo tumor models (xenograft and/or syngeneic mouse studies), including tumor implantation, caliper measurement, dosing (IP, IV, PO, SC), and terminal procedures.
• Working knowledge of IACUC protocol preparation and applicable animal welfare regulations.
• Strong data analysis and presentation skills with accurate record-keeping.
• Ability to work in a collaborative, team-based environment with excellent communication and interpersonal skills.

Benefits

Aragen Bioscience provides a stimulating work environment where employees expand their technical skills and scientific knowledge. We offer excellent salaries and benefits.

Pay

$80,000 to $110,000 depending on experience.