Associate Scientist, Protein Engineering & Binder Optimization

Key Responsibilities

• Execute high-throughput cloning, expression, and purification of recombinant proteins and binders across multiple formats.
• Perform parallelized small-scale and mid-scale protein production to support binder discovery and optimization workflows.
• Prepare purified proteins for downstream applications, ensuring appropriate quality, concentration, and documentation.
• Rigorously track samples, constructs, and yields using electronic lab notebooks and sample management systems.

Protein Characterization & Analytics

• Support binding and functional characterization efforts (e.g., sample preparation for SPR/BLI, cell-based assays, or functional screens).
• Assess protein quality, stability, and suitability for downstream assays; flag issues and propose troubleshooting steps.

Workflow Support & Continuous Improvement

• Contribute to the robustness and scalability of protein production and analytical workflows.
• Identify opportunities to improve throughput, reproducibility, or data quality through protocol refinement and standardization.
• Maintain well-organized lab spaces, reagents, and shared resources to support efficient team operation.

Collaboration & Communication

• Collaborate closely with Scientists and computational partners within the larger Protein Science team.
• Communicate experiment status, results, and issues clearly in team discussions and written records.
• Engage constructively with cross-functional partners (e.g., Cell Biology, Translational teams) as needed for sample handoff and assay support.

Basic Qualifications

• Master’s degree with 2+ years of relevant scientific experience OR Bachelor’s degree with 4+ years of relevant scientific experience.
• Hands-on laboratory experience in recombinant protein expression and purification.
• Demonstrated ability to execute repetitive, high-throughput wet-lab workflows with accuracy and consistency.
• Strong attention to detail and commitment to data quality and experimental traceability.
• Experience with parallelized or automated protein expression/purification workflows.
• Familiarity with common protein analytics and characterization methods (e.g., SEC, ELISA, biophysical assays).
• Experience working in electronic lab notebooks and sample/LIMS systems.
• Prior experience supporting protein engineering, antibody, or binder discovery programs.

Attributes for Success

• Highly reliable experimental executor who takes pride in high-quality bench work.
• Organized, methodical, and comfortable managing multiple samples and workflows in parallel.
• Learns quickly from feedback and adapts to evolving experimental needs.
• Collaborative team member who enables the productivity of Scientists and program teams.
• Motivated to build deep technical expertise in protein expression, purification, and analytics within a discovery research environment.

Pay Range

$109,650.00 - $141,900.00.