Associate Scientist - Bioanalysis

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. Orna Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company, is a biotechnology company pioneering innovative treatments for diseases that current therapies cannot effectively address. Employing groundbreaking circular RNA (circRNA) technology, along with proprietary lipid nanoparticles designed to selectively target T cells, Orna is advancing a new generation of RNA-based therapeutics focused on developing best-in-class treatments for autoimmune and oncology indications, including systemic lupus erythematosus, B-cell lymphoma, and multiple myeloma.

About the role

We are looking for a motivated Senior Scientist to join the bioanalysis team and support nonclinical studies for the company’s diverse programs. This role is 100% lab-based. The individual will actively take part in developing ligand binding assay (LBA) and PCR assays in guidance of scientists, perform sample testing, and present results in team meetings. In this role, you would have the opportunity to work with vibrant multidisciplinary teams.

Responsibilities

• Tissue processing from mice, rat, and NHP in vivo studies for RNA and protein extraction.
• Independently implement LBA and qPCR to measure large molecules such as protein and RNA from plasma and tissue samples.
• Perform method development and troubleshooting on LBA and qPCR-based assays with guidance.
• Provide high-quality bioanalytical support with a focus on quantifications for PK, TK, and PD assessment.
• Deliver and present experimental results to the preclinical team.
• Maintain detailed experimental protocols and electronic laboratory notebooks.

Requirements

• BS with 0-4+ years of related industrial or academic experience, or MS with 0-2+ years of related industrial or academic experience.
• Major in biology, chemistry, pharmaceutical science, or related fields.
• Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role.

Skills

• Experience and knowledge in RT-QPCR, ddPCR, bDNA, and Ligand Binding Assay.
• Performing data analysis using Excel and GraphPad Prism.
• Experience with Ligand Binding Assays on Luminex and MSD platforms.
• Experience in tissue sample processing is a plus.

Benefits

• Eligibility to participate in a company-sponsored 401(k) and pension.
• Vacation benefits.
• Medical, dental, vision, and prescription drug benefits.
• Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts).
• Life insurance and death benefits.
• Certain time off and leave of absence benefits.
• Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).
• Company bonus (depending, in part, on company and individual performance).

Pay

The anticipated wage for this position is $71,250 - $187,000.