Associate Scientist - Analytical & Bioanalytical Mass Spectrometry (ABMS)

About the role

The Analytical and Biological Mass Spectrometry Group (ABMS) at Regeneron Pharmaceutical's Tarrytown, NY site is seeking an Associate Scientist to join a dynamic team focused on developing and optimizing analytical methods for novel siRNA/oligonucleotide-based therapies.

Responsibilities

• Develop and optimize liquid chromatography coupled to mass spectrometry (LC-MS) related methods for the enrichment, detection, quantification, and structural characterization of siRNAs, oligonucleotides, novel siRNA conjugates, and monoclonal antibodies (mAbs)
• Perform analytical testing and sample preparation of siRNA/oligonucleotides with a focus on chromatographic fractionation, LC, LC-MS, solid phase extraction (SPE), hybridization-capture, and other mass spectrometry related methods
• Independently conduct sample preparation and LC-MS analyses in compliance with Standard Operating Procedures (SOPs) or drafted protocols, and document experimental procedures and results in an electronic laboratory notebook (ELN)

Requirements

• A BS or MS degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field with 0–3 years of relevant hands-on laboratory experience in analytical chemistry or bioanalytical sciences
• Strong hands-on experience with liquid chromatography (such as reversed-phase, size-exclusion, ion exchange chromatography), particularly HPLC or UPLC techniques
• Hands-on experience with various types of biological matrices is a plus
• Hands-on experience with fractionation, solid phase extraction, and/or hybridization techniques would be particularly valuable
• Mass spectrometry experience is beneficial, but not required; priority given to candidates with excellent chromatography skills and the ability to optimize separation methods
• Mentally flexible and adaptable to changing priorities in a fast-paced environment
• An excellent team player who can follow directions while also bringing their own insights to problem-solving
• A growth mindset and eagerness to embrace new challenges and learning opportunities
• Interest in learning about genetic medicines and development for impactful RNA-based therapies

Qualifications

• BS or MS degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field
• 0–3 years of relevant hands-on laboratory experience in analytical chemistry or bioanalytical sciences
• Experience with liquid chromatography, including HPLC or UPLC techniques
• Experience with solid phase extraction, fractionation, and hybridization techniques
• Experience with mass spectrometry is beneficial but not required

Skills

• Excellent communication skills
• Ability to work independently and communicate effectively about technical challenges and results

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include:

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits
• 401(k) company match
• Health and wellness programs
• Fitness centers
• Insurance benefits (e.g. medical, dental, vision, life and disability)
• Paid time off
• Family support benefits

Pay

$93,900.00 - $153,300.00 annually

Schedule

Full-time