Associate Principal Scientist, Regenerative Immunology

About the role

The Regenerative Immunology program at InVitro Cell Research, LLC focuses on regenerating the aging immune system, which declines and underlies many age-related diseases. We are seeking an Associate Principal Scientist to lead our Thymic Regeneration Team, tasked with restoring thymic function and rejuvenating adaptive immunity.

Responsibilities

• Lead a cutting-edge team developing iPSC-derived thymic epithelial cells (iTECs) and thymic organoids to rejuvenate the aging immune system
• Contribute highly practical and readily translatable thymic regeneration, immune reconstitution, and rejuvenative medicine ideas
• Design and optimize directed-differentiation protocols to generate functional TECs from human iPSCs
• Collaborate with other ICR scientists and groups to advance immune rejuvenation under a personalized medicine paradigm

Requirements

• A PhD or MD/PhD
• At least 10 years of research experience, preferably in thymic biology, stem cell differentiation, organoid engineering, or regenerative immunology
• Current and in-depth knowledge of thymic epithelial cell biology, iPSC directed differentiation, T-cell development, and tissue engineering
• Expert knowledge in experimental therapeutics and the landscape of developmental pipelines of practical, actionable interventions to treat and prevent age-related immune senescence and achieve immune regeneration/rejuvenation

Qualifications

• Expert knowledge of thymic epithelial cell ontogeny, FOXN1 biology, T-cell selection, and thymic niche reconstitution
• Experience with iPSC culture, directed differentiation, 3D organoid culture, single-cell genomics, RNAseq, flow cytometry, immunofluorescent microscopy, CRISPR gene editing, and cell culture
• Experience with in vivo transplantation, humanized mouse models, and assessment of functional immune reconstitution

Skills

• A friendly, easygoing personality
• The ability to work in the United States without sponsorship

Benefits

• Starting base pay range: $160,000/yr - $215,000/yr
• Starting additional compensation range: $10,000/yr - $20,000/yr

Pay

• Starting base pay range: $160,000/yr - $215,000/yr

Schedule

• Full time