Associate Director, Translational Genetics and Medicine

Overview

The Research Department at Alnylam is seeking a passionate and creative translational scientist or physician-scientist to join the Translational Genetics and Medicine Group. The role involves integrating knowledge of medicine, disease areas, and insights from human data to generate and vet novel therapeutic hypotheses. The position requires interfacing with key stakeholders across preclinical and clinical development, guiding preclinical and translational strategy, and managing workload including balancing long-term projects with time-sensitive requests.

Key Attributes And Responsibilities

• Integrate knowledge of medicine, disease areas, and insights from human data (genetics, epidemiology, clinical trials) to generate and vet novel therapeutic hypotheses.
• Interface with key stakeholders across preclinical and clinical development in early programs from lead target identification to Phase 2 clinical trials, serving as a representative for translational research, presenting to leadership, and contributing to workflows on aspects of trial design and biomarker discovery and development.
• Guide preclinical and translational strategy using medical knowledge integrated with data from biobanks, electronic health records, natural history studies, and clinical trials.
• Read the literature, derive own insights, and identify novel biological pathways and therapeutic indications for prioritization.
• Gain increasing independence and responsibility. Will be expected to manage workload including balancing long-term projects with time-sensitive requests.
• Strong written and oral presentation skills, ability to draft high quality scientific manuscripts and presentations for internal/external use.

Qualifications

• Proven track record of putting basic sciences questions in a translational/clinical context. MD or MD/PhD in medicine, pediatrics, medical genetics, or a subspeciality with sufficient exposure to a breadth of rare and common diseases.
• Non-MD applicants with substantial translational experience (8+ years in industry) in neuromuscular, cardiac, metabolic, or neuropsychiatric areas will be considered.
• Basic knowledge of clinical trial design and ability to interpret and synthesize the clinical trial landscape across multiple domains are preferred.
• Familiarity with python and/or R and basic principles of data science and experience with clinical informatics, genomics, and/or epidemiological analyses are a plus.

Pay Range

$202,300.00 - $273,700.00

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.