Associate Director/Sr. Manager, Health Economics & Outcomes Research-Oncology

Position Summary

We are seeking a strategic, analytical, and highly collaborative leader to serve as our Associate Director/Senior Manager of Health Economics & Outcomes Research (HEOR) Oncology. In this high-impact role, you will lead the development and execution of health economic and outcomes evidence demonstrating the clinical and economic value of Natera's precision molecular diagnostic technologies across oncology and emerging indications. You will develop health economic models, generate real-world and clinical-trial evidence, lead HEOR publication initiatives, and translate complex clinical and economic data into compelling evidence supporting market access, reimbursement, payer adoption, clinical adoption, and commercialization. Working across Medical Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing, Regulatory, and Business Development, you will help integrate HEOR evidence throughout the product lifecycle—from clinical development and evidence generation through publication, reimbursement, and payer adoption. This is a strategic role for an experienced HEOR professional who combines strong technical capabilities with scientific communication, business acumen, and the ability to influence cross-functional evidence strategy.

Why Join Us

At Natera, you will have the opportunity to shape the economic evidence strategy supporting innovative precision diagnostics and biomarker-guided approaches to patient care. You will work at the intersection of clinical evidence, health economics, market access, and commercialization, translating clinical innovation into measurable value for patients, providers, health systems, and payers. You will collaborate with internal leaders, investigators, key opinion leaders, and external research partners to generate evidence capable of influencing reimbursement decisions, clinical adoption, health technology assessments, and healthcare policy across U.S. and global markets.

Key Responsibilities

• Health Economic Modeling & Value Demonstration: Lead the development, validation, and application of health economic models, including budget impact, cost-effectiveness, cost-utility, cost-consequence, ROI, decision-tree, Markov/state-transition, partitioned-survival, and other economic models. Develop scenario and sensitivity analyses that quantify the clinical and economic value of precision diagnostics across different payer and healthcare-system perspectives.
• Clinical Development & HEOR Evidence Strategy: Partner with Clinical Development, Medical Affairs, Biostatistics, and other cross-functional teams to integrate HEOR objectives into prospective clinical studies, including healthcare resource utilization, economic endpoints, patient-reported outcomes, quality-of-life measures, cost-data collection, and real-world evidence strategies. Ensure evidence-generation plans anticipate future payer, reimbursement, and HTA requirements.
• Real-World Evidence & Outcomes Research: Analyze clinical-trial, observational, and real-world datasets to evaluate healthcare resource utilization, cost of care, treatment pathways, diagnostic utilization, clinical utility, comparative effectiveness, patient outcomes, survival, budget impact, and quality-adjusted life years. Translate findings into actionable evidence supporting clinical, payer, and business decisions.
• Publication & Scientific Evidence Leadership: Lead HEOR publication strategy and development of peer-reviewed manuscripts, scientific abstracts, conference posters, oral presentations, white papers, and technical reports. Coordinate publication plans and timelines with investigators, key opinion leaders, academic collaborators, and external research partners to ensure evidence generation is aligned with strategic business priorities.
• Market Access & Payer Evidence: Partner with Market Access, Medical Affairs, Marketing, and Commercial teams to translate HEOR evidence into payer value propositions, budget impact summaries, value dossiers, reimbursement materials, health economic briefs, health-system value calculators, account-specific economic tools, and other evidence-based value communications.
• Global HEOR Strategy: Develop and adapt health economic evidence and payer models for the U.S. and international markets, including Europe, Japan, Canada, Australia, and other priority geographies. Support reimbursement submissions and evidence strategies aligned with HTA and payer requirements across healthcare systems.
• Cross-Functional & External Collaboration: Serve as a strategic HEOR partner across Medical Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing, Regulatory, and Business Development. Collaborate with external consultants, academic investigators, KOLs, and research partners to execute high-quality evidence-generation initiatives.

Core Skills & Competencies

• Health Economics & Outcomes Research: Deep understanding of health economic modeling, outcomes research, healthcare resource utilization, real-world evidence, cost-of-care analysis, comparative effectiveness, and value assessment methodologies.
• Economic Modeling: Demonstrated ability to develop and critically evaluate budget impact, cost-effectiveness, cost-utility, ROI, decision-tree, Markov/state-transition, and related economic models.
• Payer & Market Access Strategy: Strong understanding of payer evidence requirements and the ability to translate clinical and economic evidence into compelling value propositions supporting reimbursement, coverage, and adoption.
• Evidence Generation & Clinical Strategy: Ability to integrate HEOR endpoints and evidence requirements into clinical development and real-world research programs, anticipating future reimbursement and HTA needs.
• Scientific Communication & Publication: Strong scientific writing and communication skills with experience translating complex analyses into manuscripts, abstracts, presentations, value dossiers, payer materials, and executive-level communications.
• Cross-Functional Leadership: Proven ability to work across clinical, medical, statistical, market access, commercial, and business functions and to influence evidence strategy in a matrixed organization.
• Global Perspective: Understanding of U.S. and international reimbursement environments and major HTA frameworks, including ICER, NICE, CADTH, PBAC, IQWiG, and Japanese reimbursement processes.

Qualifications

• Advanced degree (PhD, PharmD, MD, DrPH, or Master's degree) in Health Economics, Outcomes Research, Epidemiology, Public Health, Biostatistics, Pharmacy, Health Services Research, or a related discipline.
• 5–10+ years of HEOR experience within biotechnology, pharmaceuticals, diagnostics, medical devices, consulting, academia, or a related healthcare environment.
• Demonstrated experience developing and applying health economic models and conducting outcomes research using clinical-trial and/or real-world datasets.
• Experience supporting payer evidence generation, reimbursement strategy, value dossiers, market access initiatives, and scientific publications.
• Experience with precision medicine, molecular diagnostics, companion diagnostics, ctDNA, molecular residual disease (MRD), donor-derived cell-free DNA (dd-cfDNA), next-generation sequencing, biomarker-guided treatment strategies, or oncology diagnostics is highly desirable.
• Familiarity with advanced economic and analytical tools such as Microsoft Excel, TreeAge Pro, R, SAS, STATA, Python, SQL, Tableau/Power BI, and statistical analysis software is preferred.

Pay

Remote USA $157,000—$218,000 USD. This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

Compensation & Total Rewards

This position is also eligible for additional compensation and benefits through Natera's robust Total Rewards program, including:

• Annual performance incentive bonus
• Long-term equity awards
• Comprehensive health benefits (medical, dental, vision)
• 401(k) with company match
• Generous paid time off and company holidays
• Additional wellness and work-life benefits

Compensation Range $191,800—$239,800 USD