Analytical Chemistry Principal Research Associate

About the role

The Principal Research Associate, Analytical Chemistry will support medicinal chemistry programs through small molecule purification, analytical characterization, property assays, and workflow optimization. This role focuses on HPLC and SFC purification, with a strong emphasis on SFC expertise.

Responsibilities

• Purify small molecules using HPLC and SFC in support of medicinal chemistry programs.
• Develop and optimize SFC purification methods, including chiral and achiral separations.
• Perform analytical testing to confirm purity, identity, and quality of compounds.
• Run small molecule property assays such as solubility, lipophilicity, and stability assessments.
• Partner closely with medicinal chemists to support project timelines and compound delivery needs.
• Troubleshoot purification and assay issues and help improve lab workflows.
• Maintain accurate records and clearly communicate results to project teams.
• Support routine operation and maintenance of chromatography instruments.

Requirements

• Requires a Master's and 2+ years, or a Bachelor's and 5+ years of experience, or the equivalent combination of education and experience.
• Experience supporting small molecule discovery or medicinal chemistry programs.
• Strong hands-on experience with HPLC and/or SFC purification.
• Organizational, communication, and collaboration skills.

Skills

• Small molecule purification and characterization.
• Laboratory data systems and electronic lab notebooks.
• Familiarity with discovery informatics or compound tracking systems.
• Experience with software development, scripting, or coding.
• Ability to work effectively in cross-functional teams.
• Strong written and verbal communication skills.
• Demonstrated ability to work independently, manage priorities, and drive technical work with limited oversight.

Qualifications

• Master's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or related field.
• Minimum of 2 years of relevant experience in analytical chemistry or related field.
• Experience with HPLC and SFC purification techniques.
• Knowledge of small molecule characterization and property assays.
• Experience working in a laboratory setting.

Benefits

Vertex offers a comprehensive benefits package including medical, dental, and vision coverage, generous paid time off, student loan repayment, a generous commuting subsidy, matching charitable donations, and a 401(k) plan. The company also provides a week-long company shutdown in the Summer and the Winter, and flexible work arrangements are available for this role.

Pay

$85,700 - $128,500

Schedule

On-site, five days per week with ad hoc flexibility.