ViiV Healthcare (GSK) Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling

We need to output HTML fragment with sections only when content present. Must include h3 headings for sections like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We must not repeat job title as heading. Must not include Job ID etc. Remove boilerplate: cookie/navigation/legal/EEO/equal-opportunity/scam-warning, duplicated lines, application instructions. Must preserve all substantive info. We need to parse the posting. Key content: - Company description: ViiV Healthcare is a global specialty HIV company... (mission, culture). This could be "About the role"? Actually "About the role" is about the job description. The company description could go under "About the role" or maybe we can have a section "About the role" containing description of role and maybe company context. The instructions: Use h3 for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). So we need to decide which sections have content. We have: - Role description: "The Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling will serve in a matrix leadership role driving model-informed drug discovery across ViiV’s Drug Discovery organization by developing and applying fit-for-purpose modeling and simulation approaches that enable rapid, data-driven decision-making for HIV drug discovery programs. This predominantly discovery-focused role partners closely with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early dose predictions and to guide the design and selection of high-quality clinical candidates as rapidly as possible. You will leverage your expertise in PBPK, IVIVE, PK/PD, formulation and route-of-administration modeling to develop modeling approaches and scalable tools that accelerate decision-making from target validation through candidate selection and into early clinical development for multiple modalities (e.g., small molecules, biologics, ADCs, LNPs, and PROTACs). This role will be based in Branford, CT or Upper Providence, PA or Waltham, MA and is eligible for a domestic relocation package. This role will provide YOU the opportunity to lead key activities to progress YOUR career." That's role description. Could be under "About the role". - Responsibilities: bullet list after "These responsibilities include some of the following:" then list items. - Basic Qualification: list of required skills/qualifications. - Preferred Qualification: list. - Skills: list of skills (ADME, Analytical Chemistry, ...). Could be under Skills section. - Pay: "If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $141,075 to $235,125. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role." Thus Pay section content. - Benefits: "Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program ViiV offers US employees. All ViiV employees receive the same benefits options and plans as GSK employee." Thus Benefits section. - Schedule: Not mentioned. No schedule info. So we should not create Schedule section. - Qualifications: Could combine Basic and Preferred? The instruction: Use headings for Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We have Basic Qualification and Preferred Qualification. Could put under "Requirements" (basic) and "Qualifications" (preferred) or combine. But we need to avoid filler. We have content for both. We also have a "Skills" list separate. We also have "About the role" content (company description + role description). Might be long but okay. We must not include boilerplate like "Why You?" etc. But we need to capture the substance: The "Why You?" heading is not a standard heading; we should not output it. Instead we incorporate its content into appropriate sections (Basic Qualification, Preferred Qualification, Skills). The "Why Us?" section is also boilerplate/mission; we could incorporate into About the role maybe, but it's more about company mission. Could be part of About the role. However we must not repeat job title as heading. The "Why Us?" is not a standard heading; we can incorporate its content into About the role or maybe omit if it's just fluff. But we need to preserve ALL substantive information. The "Why Us?" includes mission statement etc. That's substantive about company. Should we include? The instruction says preserve ALL substantive information; do NOT invent or summarize away detail. So we need to keep that info somewhere. Could be part of About the role section (makes sense). However we must not create filler sections. So we can put company mission and culture under About the role. We must remove EEO/equal-opportunity, scam-warning, accommodation request, etc. Also remove lines about "Important notice to Employment businesses/ Agencies", "ViiV does not accept referrals", etc. Also remove "If you require an accommodation..." etc. Also remove "ViiV is an Equal Opportunity Employer." etc. Also remove "Important notice to Employment businesses/ Agencies". Also remove "Please note that if you are a US Licensed Healthcare Professional..." etc. Also remove "All ViiV employees receive the same benefits options and plans as GSK employee." Actually that is benefits info, we keep. We need to output only HTML fragment, no markdown fences. Let's structure:

About the role

Company description + role description.

Responsibilities

• ...

Requirements

Basic Qualification list (maybe as

).

Qualifications

Preferred Qualification list.

Skills

• ...

Pay

Salary range info + bonus etc.

Benefits

Benefits list.

We must not include Schedule. Check for any duplicated lines: we need to avoid repeating same content. Now extract content precisely. Company description paragraph: Starting from "ViiV Healthcare is a global specialty HIV company, the only one that is 100% focused on researching and delivering new medicines for people living with, and at risk of, HIV. ViiV is highly mission-driven in our unrelenting commitment to being a trusted partner for all people living with and affected by HIV. Our aim is to think, act, and connect differently through a focus on education and treatment for HIV. We go to extraordinary lengths to deliver the sorts of breakthroughs, both in treatments, care solutions and communities, that really count and take a holistic approach to HIV through developing and supporting sustainable community programs and improving access to care. We are fully committed to push through every challenge until HIV/AIDS is eradicated. ViiV has played a significant part in delivering breakthroughs that have turned HIV into a manageable health condition. We offer the largest portfolio of HIV medicines available anywhere, and we continue our work to cater for the widest possible range of needs in response to the HIV epidemic. We are aware of how much is at stake for those affected by HIV and we show up 100% committed to the patients every day. Our work culture is fast-paced, diverse, inclusive, competitive, and caring. But ViiV isn’t just somewhere to work – it’s a place to belong, an invitation to bring your very best, and a team full of impact-driven team members who are hungry to make a difference. While we have been improving lives of HIV patients for 30 years, this is an especially exciting time to be at ViiV, as we evaluate novel approaches to treatment and prevention that could further reduce the impact of HIV on individuals and communities." We can keep that as a paragraph. Then role description: "The Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling will serve in a matrix leadership role driving model-informed drug discovery across ViiV’s Drug Discovery organization by developing and applying fit-for-purpose modeling and simulation approaches that enable rapid, data-driven decision-making for HIV drug discovery programs. This predominantly discovery-focused role partners closely with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early dose predictions and to guide the design and selection of high-quality clinical candidates as rapidly as possible. You will leverage your expertise in PBPK, IVIVE, PK/PD, formulation and route-of-administration modeling to develop modeling approaches and scalable tools that accelerate decision-making from target validation through candidate selection and into early clinical development for multiple modalities (e.g., small molecules, biologics, ADCs, LNPs, and PROTACs). This role will be based in Branford, CT or Upper Providence, PA or Waltham, MA and is eligible for a domestic relocation package. This role will provide YOU the opportunity to lead key activities to progress YOUR career." We can combine after company description. Now Responsibilities list: - Develop and apply fit-for-purpose mechanistic and translational models (PBPK, IVIVE, PK/PD) to guide drug discovery teams toward the highest-quality clinical candidates - Translate complex ADME, PK, PD, and translational data into actionable insights for project teams and senior leadership - Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long-acting therapies - Build scalable computational tools, workflows, and prototypes that accelerate discovery decisions and candidate optimization - Establish best practices, standards, and governance for modeling methodologies, tools, and computational workflows - Contribute to scientific publications, regulatory submissions, and other technical documentation, and represent ViiV externally through regulatory interactions and scientific thought leadership Now Basic Qualification (Required): - Master’s degree with 7 or more years of post-graduate experience, or a PhD with 4 or more years of post-graduate experience, supporting drug discovery programs from lead optimization to Phase I clinical studies - Strong understanding of ADME principles and integration of standard DMPK workflows and data streams into empirical (e.g. NCA, compartmental modeling) and mechanistic modeling and simulation (e.g. PBPK, QSP) approaches to support rapid discovery decision-making - Demonstrated ability to apply modeling and simulation approaches to influence key drug discovery decisions, including lead optimization, candidate selection, dose projection, and development strategy - Broad computational programming expertise in programming and modeling languages (e.g., R, Python, or equivalent) and modeling platforms (e.g., Simcyp, GastroPlus, Phoenix WinNonLin, etc.) to develop modeling and analysis workflows - Experience integrating diverse datasets (in vitro, in vivo, clinical, omics where applicable) into unified predictive modeling platforms - Ability to interpret and communicate modeling results to cross-functional teams, and through written communication such as internal reports and publications Preferred Qualification: - PhD with 6 or more years of drug discovery experience in DMPK or a related discipline - Demonstrated experience developing and applying modeling and simulation strategies across diverse modalities and routes of administration, including oral therapies, long-acting injectables, biologics, ADCs, lipid nanoparticles, and other advanced therapeutic platforms - Experience working across teams, including matrix and functional leadership, and partnering with internal and external experts to deliver quality candidates with speed - Excellent written, verbal, and presentation skills, including experience communicating scientific concepts to cross-functional teams and key stakeholders - Experience in infectious disease and/or immunology therapeutic areas Skills list: "ADME, Analytical Chemistry, Drug Design, Drug Discovery Process, Drug Metabolism, Drug Research, Drug Target Identification, Metabolism, PBPK Modeling, Pharmaceutical Products, Pharmacokinetics, Pharmacology, Pharmacovigilance, Target Research" We can output as
• ADME
... etc. Pay: "If you are based in Cambridge, MA