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ViiV Healthcare (GSK) Scientific Leader, Nonclinical Drug Discovery Modeling

GSK · Branford, CT · 2 wk ago
ScienceFull-time

About the role

ViiV Healthcare is seeking a Scientific Leader, Nonclinical Drug Discovery Modeling to join our team. This role contributes to Model-Informed Drug Discovery (MIDD) across ViiV Discovery by developing and applying fit-for-purpose modeling and simulation approaches that enable rapid, data-driven decision-making for HIV drug discovery programs.

Responsibilities

  • Apply fit-for-purpose modeling and simulation approaches to support decision-making across HIV discovery programs.

  • Develop and execute mechanistic and translational models (e.g., PBPK, IVIVE, PK/PD) to support dose prediction, compound optimization, and candidate selection.

  • Integrate experimental data into predictive workflows and translate ADME, PK, PD, and translational data into actionable project insights.

  • Apply modeling expertise across diverse modalities, formulations, and routes of administration, including long-acting therapies.

  • Guide program teams toward the identification and advancement of high-quality clinical candidates.

  • Contribute to modeling workflows, computational tools, and reproducible coding practices.

  • Collaborate with Chemistry, Biology, DMPK, and Clinical Pharmacology teams to support program objectives and dose prediction strategies.

  • Communicate modeling results and recommendations to multidisciplinary project teams.

  • Contribute to scientific publications, regulatory documentation, and knowledge sharing within the modeling community.

Qualifications

  • MS Degree & 7 plus years of experience or PhD & 4 plus years of experience (post-graduation) supporting drug discovery programs.

  • Experience with modeling platforms (e.g., SimCYP, GastroPlus, WinNonLin, etc.) and basic scripting experience (e.g., R, MATLAB, Python).

  • Ability to apply mechanistic modeling approaches to support discovery programs and to progress rapid decisions.

  • Familiarity with reproducible coding practices and version control.

  • Experience in PK/PD, PBPK, or IVIVE modeling approaches.

  • Ability to interpret results and communicate to cross-functional teams.

Preferred Qualifications

  • PhD & 6 plus years of drug discovery experience.

  • Experience working across teams, including partnering with internal and external experts.

  • Excellent written, verbal, and presentation skills, including experience communicating scientific concepts to cross-functional teams and stakeholders.

  • Strong data visualization and numerical analysis capabilities are highly valued.

Why Us?

We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS. At ViiV Healthcare, we do things differently. Born out of a partnership between GSK and Pfizer in 2009, with Shionogi joining in 2012, we are determined to help end the HIV epidemic. We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS.

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