USDA-ARS Postdoctoral Research Computational Biology Fellowship
Research Project
Research will focus on the development of bioinformatics and genomics tools to characterize the structure and function of the ruminant genomes and the application of those datasets to accelerate genetic improvement and discover genetic variation affecting economically important traits.
Under the guidance of a mentor, the fellow will have the opportunity to be involved in the following aspects of the project:
- Developing and customizing pipelines for automation of data processing required for discovering genetic (e.g., SNP, CNV) and epigenetic (e.g., DNA methylation) variations, as well as generating genome assemblies and pangenomes using short- and long-read sequencing in cattle and other ruminants.
- Developing better statistical methods to incorporate new reference genomes, pangenomes and improve association studies with QTL and enhancing genetic prediction tools for automation of data processing required for SNP use in livestock selection programs.
Learning Objectives
- Explain the structure and functional organization of the bovine genome and describe how genomic tools are used to characterize genetic and epigenetic variation.
- Identify and differentiate types of genomic variation (e.g., SNPs, CNVs, DNA methylation patterns) and functional genomic elements (e.g., enhancers, promoters) in cattle.
- Customize bioinformatics pipelines for automated processing and analysis of short- and long-read sequencing data.
- Apply computational approaches to detect genetic and epigenetic variation from sequencing datasets in livestock species.
- Generate genome assemblies from long-read sequence data and build pangenomes.
- Design and implement statistical methods for QTL mapping and association studies, and interpret their results in the context of economically important traits.
- Evaluate and improve genomic prediction models for use in livestock selection programs.
- Integrate genomic data into applied breeding strategies to accelerate genetic improvement in cattle.
Mentor(s)
The mentor for this opportunity is Benjamin Rosen (ben.rosen@usda.gov).
Anticipated Appointment Start Date
June 2026. Start date is flexible and will depend on a variety of factors.
Appointment Length
The appointment will initially be for one year, but may be renewed upon recommendation of ARS and is contingent on the availability of funds.
Level of Participation
The appointment is full time.
Participant Stipend
The participant will receive a monthly stipend commensurate with educational level and experience. The anticipated stipend range is $63,940 - $68,202 annually.
Citizenship Requirements
This opportunity is available to U.S. citizens only.
ORISE Information
This program, administered by ORAU through its contract with the U.S. Department of Energy (DOE) to manage the Oak Ridge Institute for Science and Education (ORISE), was established through an interagency agreement between DOE and ARS. Participants do not become employees of USDA, ARS, DOE or the program administrator, and there are no employment-related benefits. Proof of health insurance is required for participation in this program. Health insurance can be obtained through ORISE.
Questions
Please visit our Program Website. After reading, if you have additional questions about the application process, please email ORISE.ARS.Northeast@orau.org and include the reference code for this opportunity.