UNIV - Staff Scientist I - Department of Medicine: Division of Hematology Oncology

Job Duties

• In vivo mouse tumor models
• Ex vivo and in vitro tumor models
• laboratory management
• Independently troubleshoots technical problems, such as equipment malfunctions and issues in experimental assays.
• Develops new research directions for the development and evaluation of novel small molecule, large molecule, and cellular therapeutics, as well as developing and adapting experimental models and methodologies to carry out these investigations.
• Data analysis and manuscript preparation. Including but not limited to: Graphing and visualization of data with software including Graphpad Prism, FlowJo, Snapgene, Biorender, Microsoft Powerpoint, Microsoft Excel, and Adobe Illustrator
  Presenting data during lab meetings
  Preparing publication quality figures, may be involved in writing of manuscripts
  Efforts will directly contribute to grant applications and manuscripts
• Affords assistance in the supervision and training of new lab members.

Preferred Knowledge, Skills, And Abilities

• Together with the PI, assist with management of laboratory staff, including training, scheduling (lab meetings), and performance evaluations.
• Oversee day-to-day laboratory operations, including maintenance of equipment, inventory management, and ordering supplies.
• Ensure compliance with safety protocols and regulatory requirements in the laboratory.
• Collaborate with principal investigators and research teams to facilitate project execution and data collection.
• Afford assistance in the development and implementation of research protocols and standard operating procedures (SOPs).
• Maintain laboratory budgets and expenditures.
• Facilitate communication between laboratory personnel and administrative staff.
• Afford assistance in the design, execution, and analysis of experiments utilizing mouse models to study cancer progression and treatment responses, including tumor implantation, monitoring, and endpoint analysis for efficacy (tumor volume, survival) and correlative (immunophenotyping, single cell RNA-sequencing) studies using established and novel mouse models of cancer.
• Collaborate with multidisciplinary teams, including molecular biologists, biochemists, and clinical researchers, to support translational research efforts.
• Manage and care for the mouse colony, ensuring compliance with ethical standards and institutional animal care regulations.
• Document and present research findings in internal meetings, conferences, and peer-reviewed publications.
• Afford assistance in mentoring junior scientists and students in laboratory techniques and research methodologies.
• Stay current with advancements in cancer biology and laboratory technologies, including but limited to: Ex vivo 3D microfluidic culture, drug/antibody treatment of murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS) and cell line derived monotypic tumor spheroids (MTS)
• Perform requisite fluorescence-based viability assessment of MDOTS, PDOTS, and MTS, including staining, microscope operation, image acquisition and image analysis
• Maintain internal records related to MDOTS, PDOTS, and MTS processing along with associated meta-data