Scientist I – Immuno-Oncology & Microtumor Systems

Responsibilities

• Model Engineering & Co-Culture Development: Formulates experimental protocols to engineer adaptable, immune-inclusive microtumor co-cultures utilizing controlled perfusion. Integrates autologous T cells, B cells, NK cells, and diverse myeloid populations (including macrophages).
• Advanced Immunophenotyping & Data Analysis: Processes and interprets high-resolution experimental data. Utilizes flow cytometry, mass cytometry (CyTOF), and single-cell transcriptomics (scRNA-seq) to resolve cellular activation, macrophage polarization, and exhaustion trajectories.
• Functional & Functional Kinetic Assays: Conducts longitudinal live-cell imaging, spatial cytokine profiling, and high-throughput tumor-killing assays to quantify immune cell trafficking, tumor infiltration, and antigen-specific cytotoxicity.
• Clinical Benchmarking & Validation: Maintained detailed documentation to benchmark immune-microtumor responses against patient-matched clinical outcome data, rigorously validating the model's predictive value.
• Laboratory Leadership: Trains and supervises laboratory technicians, ensures documentation fulfills industry standards, and maintains detailed workbooks.
• Communication & Funding: Prepares high-quality written reports, presentations, and manuscripts for scientific journals. Coordinates and contributes to new grant and funding applications supporting project priorities.

Qualifications

• Education and Experience: Doctorate Degree required. Minimum of 2-5 years experience required.
• Required Knowledge, Skills And Abilities: Specialized Technical Skills: Proven experience with complex cell culture systems, such as organoids, 3D co-cultures, or organ-on-a-chip/perfusion platforms from primary tissue. High resolution microscopy using Aryscan Zeiss imaging and image processing tools. Metabolomics approaches using Seahorse for primary tissue and organoid. Advanced Immuno-Oncology Expertise: Deep knowledge of tumor-immune microenvironments, immune cell transport, checkpoint immunomodulation (PD-1/PD-L1), and cellular therapies (CAR T). Hands-on proficiency with multi-parameter flow cytometry, mass cytometry (CyTOF), and/or single-cell sequencing technologies (scRNA-seq). Experience with longitudinal live-cell imaging using Incucyte and image analysis software is highly desirable. Analytical Skills: Ability to troubleshoot complex technical procedures and interpret multi-omic, spatial, and kinetic datasets. Communication: Excellent written and verbal communication skills for cross-functional collaboration and manuscript/grant preparation. Ability to work independently, manage timelines across multiple specific aims, and oversee technical staff. Ability to obtain and maintain a T1/Public Trust background check.