TEMP - Senior Scientist, Computational Chemistry (Remote, Hybrid, or San Diego)

About the role

The successful candidate will be responsible for the execution of computational driven methodologies to help design optimized compounds with balanced properties (targets, DMPK, in-vivo) in drug discovery programs, that could range from early lead identification to late-stage optimization phase. Will be a member of multi-disciplinary drug discovery teams of medicinal chemists, DMPK, structural biologists and pharmacologists, where opportunities to impact will abound.

Responsibilities

• Experience with Molecular Modeling domains is required, as applied to compound design and optimization such as Pharmacophore Analyses, Library Design, virtual HTS, Diversity/Similarity Analyses, Scaffold Hopping.
• A demonstrated success with an overall application of several integrated approaches (ex: ML derived predictions, Modeling SBD/ LBD) to progressing compound design contextual in drug discovery, is highly desirable and will serve as a strong bonus to consideration.
• Publishations, posters or documented examples would be helpful.
• Preference also given to candidates with previous roles in biotech/pharma companies and capable of independently driving forward Drug Discovery projects involving Structure Based Design including, but not limited to, target protein flexibility considerations.
• Exposure to harnessing large datasets including public domain datasets of chemistry related to various targets and/or chemogenomic nature would be an asset.
• Knowledge about computational technologies for the assessment of early-stage targets (ex: druggability) is helpful but not essential.
• Familiarity with well-known commercial molecular modeling software suites is also desirable such as Schrodinger, CCG or Open Eye.

Qualifications

• BS/BA degree in Chemistry and 5+ years of relevant experience, including familiarity utilizing any or all of the following: Machine Learning/AI based predictive modeling, Cheminformatics, Protein-Ligand modeling is preferred OR
• ORMS/MA degree in Chemistry and 3+ years of similar experience noted above OR
• 3+ years of post-Ph.D experience preferred
• Recognizes fundamental anomalies in data points and identifies issues in experiments / processes
• Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals
• Strong knowledge of scientific discipline
• Good knowledge of scientific principles, methods and techniques
• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools
• Strong computer skills
• Good problem-solving, analytical thinking skills
• Detail oriented
• Ability to meet deadlines
• Excellent communication skills with the ability to collaborate with cross-functional scientists

Benefits

The pay you should reasonably expect to receive is $53.26 - $77.21 per hour. Decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.

Schedule

N/A

Skills

N/A

Pay

$53.26 - $77.21 per hour