TEMP - Scientist, Bioconjugation Purification

About the role

The Scientist, Bioconjugation Purification, supports the discovery and development of novel antibody-based therapeutics through the purification, characterization, and formulation of antibodies and bioconjugates.

Responsibilities

• Design, execute, and optimize purification processes for antibodies and bioconjugates using a variety of chromatographic and filtration techniques
• Purify and formulate antibodies, ADCs, APCs, AOCs, and related bioconjugate modalities to support discovery and preclinical development activities
• Characterize purified products using established analytical methods and interpret data to assess product quality, purity, identity, and conjugation attributes
• Analyze experimental results, troubleshoot technical challenges, and recommend process improvements to enhance product recovery, purity, and overall process performance
• Generate, organize, and communicate scientific data through technical reports, presentations, and electronic laboratory documentation
• Collaborate effectively with scientists across bioconjugation, protein engineering, analytical, and other cross-functional teams to support project objectives
• Evaluate and implement new purification and characterization technologies to improve workflow efficiency and product quality
• Maintain accurate laboratory records, batch documentation, and inventory in accordance with company procedures and quality standards
• Comply with all safety, quality, and operational requirements while contributing to a productive and collaborative laboratory environment
• Manage laboratory inventories of consumables, reagents, and chemicals, and coordinate procurement activities in accordance with departmental procedures and established guidelines to ensure efficient laboratory operations

Requirements

• BS/BA degree in biology and 2+ years of relevant experience OR MS/MA degree in biology and some relevant industry experience preferred OR PhD or equivalent and some relevant experience
• Knowledge of the principles of Biology, Biochemistry, Molecular Biology, Chemical Biology, Bioengineering, or related field
• Demonstrated experience in purification of monoclonal/complex antibodies, antibody fragments, recombinant proteins, and/or bioconjugates and understanding of scale-up principles
• Knowledge of protein chemistry, antibody structure-function relationships, and bioconjugation principles is a plus
• Hands-on experience in preparative and analytical chromatography techniques including affinity chromatography, ion exchange chromatography (CEX and AEX), Hydrophobic interaction chromatography (HIC), size exclusion chromatography (SEC) and mixed-mode/multimodal chromatography
• Experience operating and troubleshooting chromatography systems such as ÄKTA Pure, ÄKTA Avant, or equivalent systems
• Proficiency with tangential flow filtration (TFF), ultrafiltration/diafiltration (UF/DF), and buffer exchange processes
• Experience characterizing proteins and bioconjugates using analytical methods including: SEC-HPLC, HIC-HPLC for DAR determination, Reverse-phase HPLC, UV-Vis spectroscopy, endotoxin testing (LAL or equivalent)
• Familiarity with analytical mass spectrometry for intact mass, subunit analysis, and conjugate characterization a plus
• Demonstrated ability to analyze, interpret, and present complex purification and characterization data
• Strong organizational skills with the ability to manage multiple projects and competing priorities simultaneously
• Ability to independently design experiments, troubleshoot technical issues, and recommend process improvements
• Demonstrated scientific rigor, attention to detail, and commitment to data integrity and reproducibility
• Demonstrated ability to maintain a clean, organized, and efficient laboratory environment while managing multiple priorities
• Collaborative team player who builds positive working relationships across functional groups and contributes to a productive team culture
• Demonstrated ability to work effectively in a highly interactive, fast-paced research environment
• Adaptable and receptive to feedback, with a continuous improvement mindset and eagerness to learn new techniques and technologies
• Proactive, approachable, and engaged, with a willingness to actively participate in scientific discussions and team activities

Pay

$43.17 - $62.55 per hour

Schedule

Full-time

Benefits

N/A

Skills

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Benefits

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