SVP, Medical Affairs

Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases.

About the role

Legend Biotech is seeking a Senior Vice President, Medical Affairs to provide enterprise leadership for the Company's global Medical Affairs organization. This role is a critical enterprise leadership position with significant impact on the scientific, clinical, and external medical strategy for Legend’s approved BCMA CAR-T in multiple myeloma, as well as the development of future pipeline programs. The SVP will set the overall Medical Affairs vision and strategy, partner closely with collaboration partners such as Johnson & Johnson and internal cross-functional leaders, and ensure Medical Affairs is positioned as a strategic driver of clinical understanding, external engagement, lifecycle planning, data generation, and future growth.

The SVP, Medical Affairs will report to the President of the Carvykti Business Unit, will be a member of the Carvykti Leadership Team, and will be based in Bridgewater, NJ.

Responsibilities

• Define and execute the Medical Affairs vision, strategy, and operating model across CARVYKTI and the broader pipeline.
• Provide enterprise leadership for lifecycle management, evidence generation, scientific communications, medical launch excellence, and external medical engagement.
• Partner with R&D, Commercial, Regulatory, Safety, Market Access, and Clinical Development to shape product strategy and maximize portfolio value.
• Ensure medical insights and scientific expertise influence key business and development decisions.
• Serve as the senior scientific leader and external ambassador for Medical Affairs.
• Build and maintain relationships with key opinion leaders (KOLs), academic institutions, professional societies, patient advocacy groups, and healthcare stakeholders.
• Lead the global evidence-generation, publication, and scientific communication strategy.
• Promote scientific excellence, patient-centered innovation, compliance, and thought leadership across the organization.
• Build and lead a high-performing Medical Affairs organization capable of supporting current and future business needs.
• Develop organizational capabilities across Medical Strategy, Field Medical, Medical Communications, Evidence Generation, Medical Operations, and Medical Excellence.
• Establish talent, succession, leadership development, and capability-building strategies to strengthen organizational effectiveness and future readiness.
• Drive a culture of accountability, continuous learning, innovation, and high performance.
• Serve as a key member of the Carvykti Business Unit leadership team, contributing to enterprise strategy and organizational decision-making.
• Lead Medical Affairs transformation initiatives, including digital innovation, omnichannel engagement, advanced analytics, and operational excellence.
• Foster strong collaboration across internal functions, alliance, and external partners to drive alignment and execution.
• Ensure effective governance, resource prioritization, performance management, and delivery against strategic objectives.
• Operate as an enterprise leader with a global mindset.
• Influence company strategy through scientific leadership and medical insights.
• Drive organizational excellence and execution across a highly matrixed environment.
• Champion innovation, patient centricity, and continuous improvement.
• Develop future medical leaders and strengthen organizational capability.
• Promote a culture of accountability, inclusion, innovation, collaboration, and high performance.

Requirements

• MD (preferred), PharmD, PhD, or equivalent advanced scientific degree required; board certification and oncology/hematology experience strongly preferred.
• 15+ years of progressive leadership experience in Medical Affairs, Clinical Development, or related biopharmaceutical leadership roles.
• Significant leadership experience in oncology, hematology, cell therapy, or specialty biopharmaceuticals, including responsibility for global Medical Affairs organizations spanning field medical, scientific communications, publications, evidence generation, and external engagement.
• Demonstrated success shaping treatment landscapes, supporting product launches and lifecycle management, building high-performing organizations, and developing capabilities to support current and future portfolio growth.
• Experience working effectively across complex global partnerships, matrix organizations, and cross-functional leadership teams.
• Deep understanding of pharmaceutical development and Medical Affairs, with experience across multiple functions such as Clinical Development, Medical Affairs, Regulatory, Commercial, Safety, Translational Development, or Market Access.
• Strong scientific credibility with expertise in medical strategy, evidence generation, scientific communications, external stakeholder engagement, and product lifecycle management.
• Prior experience supporting NDA/BLA submissions, launches, and post-launch lifecycle strategies preferred.
• Established relationships within the oncology and hematology community, particularly multiple myeloma and/or cellular therapy, preferred.
• Proven ability to influence senior executives, drive alignment across complex stakeholder groups, and lead organizational transformation and capability-building initiatives.
• Exceptional communication, leadership, negotiation, change management, and collaboration skills, with a demonstrated ability to deliver results across global, matrixed environments.
• Strong business acumen, analytical capability, and ability to translate clinical and scientific insights into impactful medical and business strategies.

Benefits

• Medical, dental, and vision insurance.
• 401(k) retirement plan with a company match that vests fully on day one.
• Eight (8) weeks of paid parental leave after three (3) months of employment.
• Paid time off policy including vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays.
• Additional voluntary benefits including flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance.
• Voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs.

Pay

Base pay range: $389,454 USD - $511,158 USD. Performance-based bonus and/or equity is available to employees in eligible roles.

Applicants must be authorized to work in the United States. Legend Biotech participates in the E-Verify program.