Staff / Senior Scientist, Bioconjugation Chemistry

Back to jobs Staff / Senior Scientist, Bioconjugation Chemistry Berkeley, CA About Glyphic: At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What We Are Looking For In You We are seeking a Senior or Staff Scientist, Bioconjugation to join our Chemistry team at a pivotal stage in assay development. Reporting to the Senior Director of Chemistry, you will be a hands-on expert who designs, develops, and executes bioconjugation strategies for peptide and oligonucleotide components that are central to our single-molecule proteome sequencing assay. The ideal candidate brings deep expertise in protein and peptide bioconjugation, site-specific chemical modification of amino acid sidechains, and oligonucleotide-biomolecule conjugation, with a track record of working in complex, multi-component systems (e.g., ADCs, therapeutic bioconjugates, or new bioconjugated components for assays). A successful candidate will have an innovative method-development mindset and will effectively build new approaches to making bioconjugates. This individual will thrive in a cross-functional environment where chemical solutions must be tightly integrated into assay design. This role offers the unique opportunity to develop first-in-class conjugation chemistry that enables single-molecule protein sequencing. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location. What You’ll Do Bioconjugation strategies: Partner with sample prep and assay development to screen and select conjugation chemistries for peptides and oligonucleotides that enable single molecule protein sequencingDesign bioconjugation workflows using NHS-ester chemistry, maleimides, isothiocyanate chemistry, and click chemistry (CuAAC, SPAAC, IEDDA) Prepare bioconjugation reagents to enable studies from proof-of-concept through prototype-kitting. Peptide Chemistry: Develop labeling strategies based on Edman ChemistryDevelop and apply selective C-terminal and N-terminal conjugation chemistriesDevelop site-specific labeling strategies for amino acid sidechains (Cys, Lys, Arg, Tyr, Trp, His, Asp/Glu) on native peptides. Screen protecting groups to enhance amino acid signal in the protein sequencing assayEnable on-bead workflow to label and release peptides for interrogation in the sequencing assay Synthesize, Characterize, And Scale: Synthesize and purify peptide and oligonucleotide conjugates for assay testingCharacterize conjugation efficiency, purity, and stability using tools such as HPLC, LC-MS/MS, NMR, CE, UV/Vis, and FTIRScale conjugate synthesis from R&D quantities to prototype-grade supply for internal testing, with attention to reproducibility, shelf-life, and fit-for-purpose quality Collaborate And Document: Work cross-functionally with sample preparation, assay integration, and reagent manufacturing teams to troubleshoot conjugation failures and optimize workflowsContribute to intellectual property development through invention disclosuresMaintain rigorous experimental documentation in Confluence and laboratory notebooks; author and maintain SOPs for new conjugation methods Required: What you need MS or PhD in organic chemistry, chemical biology, biochemistry, or a related fieldIndustry experience in bioconjugation chemistry, with demonstrated ability to independently design, develop, and troubleshoot conjugation workflowsMS/PhD with 8+/6+ years of experience (for Staff Scientist)MS/PhD with 6+/4+ years of experience (for Senior Scientist)Deep expertise in protein and/or peptide bioconjugation: NHS esters, maleimides, click chemistries (CuAAC, SPAAC, IEDDA), isothiocyanate coupling, and related bioorthogonal approachesExperience with site-specific amino acid sidechain chemistry beyond maleimide chemistry (e.g. Cys, Lys, Arg, Tyr, Trp, Asp/Glu) for application in multistep workflowsTrack record developing novel blocking groups and conducting SAR studies to optimize blocking group performance and selectivityProficiency in analytical characterization: HPLC method development, LC-MS/MS for conjugate analysis, UV/Vis, and CEMethod-development mindset: history of building and adapting new chemical approaches rather than executing established protocolsDemonstrated ability to function as an independent contributor and collaborative partner in a cross-functional team setting Nice To Have: Hands-on experience with solid-phase peptide synthesis (SPPS), including protecting group strategies beyond standard Fmoc/Boc and selective on-resin modificationsExperience with peptide C-terminal chemistry manipulation methods: thioester formation, native chemical ligation, or photoredox/iridium-catalyzed C-terminal labelingFamiliarity with oligonucleotide chemistry and oligo-conjugation techniques (ITC, phosphoramidite modifications, click coupling to nucleic acids)Experience with scalable surface chemistry methods for flow cells or solid-phase supportsFamiliarity with statistical and DOE-based experimental design for chemistry optimizationPrior experience in an early-stage biotech or tools/diagnostics company We’re Looking For a Teammate That: Navigates complex team dynamics, partnerships, and challenges with creativity and logic.Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.Treats obstacles as problems to be creatively solved, not reasons something can’t be done.Applies sound judgment to the best available information, testing, learning, and iterating.Shares early and directly when assumptions change, results are unclear, or timelines are at risk. Work Environment: What you can expect from this role Collaborative culture where your ideas and expertise are valuedDirect impact on product development and company direction Professional Growth: Learn from a diverse team of world-class scientists and engineersContribute to first-of-their kind technologies, high-impact publications, and patents Compensation Estimated Base Salary $123,000 - $187,575 This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas. Benefits And Perks: Employee Stock Option Plan100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)Employer Retirement Contributions to 401(k)Generous Paid Time OffPaid Maternity and Paternity LeaveHealth & Wellbeing ProgramOffice Snacks and BeveragesRegular Team Bonding Activities We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. Apply for this job indicates a required field First Name* Last Name* Preferred First Name Email* Phone Country* Phone* 244 results found No results found Afghanistan+93Åland Islands+358Albania+355Algeria+213American Samoa+1Andorra+376Angola+244Anguilla+1Antigua & Barbuda+1Argentina+54Armenia+374Aruba+297Ascension Island+247Australia+61Austria+43Azerbaijan+994Bahamas+1Bahrain+973Bangladesh+880Barbados+1Belarus+375Belgium+32Belize+501Benin+229Bermuda+1Bhutan+975Bolivia+591Bosnia & Herzegovina+387Botswana+267Brazil+55British Indian Ocean Territory+246British Virgin Islands+1Brunei+673Bulgaria+359Burkina Faso+226Burundi+257Cambodia+855Cameroon+237Canada+1Cape Verde+238Caribbean Netherlands+599Cayman Islands+1Central African Republic+236Chad+235Chile+56China+86Christmas Island+61Cocos (Keeling) Islands+61Colombia+57Comoros+269Congo - Brazzaville+242Congo - Kinshasa+243Cook Islands+682Costa Rica+506Côte d’Ivoire+225Croatia+385Cuba+53Curaçao+599Cyprus+357Czechia+420Denmark+45Djibouti+253Dominica+1Dominican Republic+1Ecuador+593Egypt+20El Salvador+503Equatorial Guinea+240Eritrea+291Estonia+372Eswatini+268Ethiopia+251Falkland Islands+500Faroe Islands+298Fiji+679Finland+358France+33French Guiana+594French Polynesia+689Gabon+241Gambia+220Georgia+995Germany+49Ghana+233Gibraltar+350Greece+30Greenland+299Grenada+1Guadeloupe+590Guam+1Guatemala+502Guernsey+44Guinea+224Guinea-Bissau+245Guyana+592Haiti+509Honduras+504Hong Kong SAR China+852Hungary+36Iceland+354India+91Indonesia+62Iran+98Iraq+964Ireland+353Isle of Man+44Israel+972Italy+39Jamaica+1Japan+81Jersey+44Jordan+962Kazakhstan+7Kenya+254Kiribati+686Kosovo+383Kuwait+965Kyrgyzstan+996Laos+856Latvia+371Lebanon+961Lesotho+266Liberia+231Libya+218Liechtenstein+423Lithuania+370Luxembourg+352Macao SAR China+853Madagascar+261Malawi+265Malaysia+60Maldives+960Mali+223Malta+356Marshall Islands+692Martinique+596Mauritania+222Mauritius+230Mayotte+262Mexico+52Micronesia+691Moldova+373Monaco+377Mongolia+976Montenegro+382Montserrat+1Morocco+212Mozambique+258Myanmar (Burma)+95Namibia+264Nauru+674Nepal+977Netherlands+31New Caledonia+687New Zealand+64Nicaragua+505Niger+227Nigeria+234Niue+683Norfolk Island+672North Korea+850North Macedonia+389Northern Mariana Islands+1Norway+47Oman+968Pakistan+92Palau+680Palestinian Territories+970Panama+507Papua New Guinea+675Paraguay+595Peru+51Philippines+63Poland+48Portugal+351Puerto Rico+1Qatar+974Réunion+262Romania+40Russia+7Rwanda+250Samoa+685San Marino+378São Tomé & Príncipe+239Saudi Arabia+966Senegal+221Serbia+381Seychelles+248Sierra Leone+232Singapore+65Sint Maarten+1Slovakia+421Slovenia+386Solomon Islands+677Somalia+252South Africa+27South Korea+82South Sudan+211Spain+34Sri Lanka+94St. Barthélemy+590St. Helena+290St. Kitts & Nevis+1St. Lucia+1St. Martin+590St. Pierre & Miquelon+508St. Vincent & Grenadines+1Sudan+249Suriname+597Svalbard & Jan Mayen+47Sweden+46Switzerland+41Syria+963Taiwan+886Tajikistan+992Tanzania+255Thailand+66Timor-Leste+670Togo+228Tokelau+690Tonga+676Trinidad & Tobago+1Tunisia+216Turkey+90Turkmenistan+993Turks & Caicos Islands+1Tuvalu+688U.S. Virgin Islands+1Uganda+256Ukraine+380United Arab Emirates+971United Kingdom+44United States+1Uruguay+598Uzbekistan+998Vanuatu+678Vatican City+39Venezuela+58Vietnam+84Wallis & Futuna+681Western Sahara+212Yemen+967Zambia+260Zimbabwe+263 Location (City)* Resume/CV* Attach Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Enter manually Accepted file types: pdf, doc, docx, txt, rtf LinkedIn Profile Website How did you hear about this job? Are you legally authorized to work for Glyphic Biotechnologies in the United States?* Select... Will you require sponsorship for employment visa status now or in the future?* Select... If offered a position with Glyphic Biotechnologies, I understand my employment may be contingent upon a reference check, and any other required check or screening specified in the job description, the offer letter and/or discussed during the interview process.* Select... Do you have experience with protein or peptide bioconjugation?* Select... What site-specific amino acid sidechain chemistries have you used most?* Bioconjugation Strategies: Partner with sample prep and assay development to screen and select conjugation chemistries for peptides and oligonucleotides that enable single molecule protein sequencingDesign bioconjugation workflows using NHS-ester chemistry, maleimides, isothiocyanate chemistry, and click chemistry (CuAAC, SPAAC, IEDDA) Prepare bioconjugation reagents to enable studies from proof-of-concept through prototype-kitting. Peptide Chemistry: Develop labeling strategies based on Edman ChemistryDevelop and apply selective C-terminal and N-terminal conjugation chemistriesDevelop site-specific labeling strategies for amino acid sidechains (Cys, Lys, Arg, Tyr, Trp, His, Asp/Glu) on native peptides. Screen protecting groups to enhance amino acid signal in the protein sequencing assayEnable on-bead workflow to label and release peptides for interrogation in the sequencing assay Synthesize, Characterize, And Scale: Synthesize and purify peptide and oligonucleotide conjugates for assay testingCharacterize conjugation efficiency, purity, and stability using tools such as HPLC, LC-MS/MS, NMR, CE, UV/Vis, and FTIRScale conjugate synthesis from R&D quantities to prototype-grade supply for internal testing, with attention to reproducibility, shelf-life, and fit-for-purpose quality Collaborate And Document: Work cross-functionally with sample preparation, assay integration, and reagent manufacturing teams to troubleshoot conjugation failures and optimize workflowsContribute to intellectual property development through invention disclosuresMaintain rigorous experimental documentation in Confluence and laboratory notebooks; author and maintain SOPs for new conjugation methods Required: MS or PhD in organic chemistry, chemical biology, biochemistry, or a related fieldIndustry experience in bioconjugation chemistry, with demonstrated ability to independently design, develop, and troubleshoot conjugation workflowsMS/PhD with 8+/6+ years of experience (for Staff Scientist)MS/PhD with 6+/4+ years of experience (for Senior Scientist)Deep expertise in protein and/or peptide bioconjugation: NHS esters, maleimides, click chemistries (CuAAC, SPAAC, IEDDA), isothiocyanate coupling, and related bioorthogonal approachesExperience with site-specific amino acid sidechain chemistry beyond maleimide chemistry (e.g. Cys, Lys, Arg, Tyr, Trp, Asp/Glu) for application in multistep workflowsTrack record developing novel blocking groups and conducting SAR studies to optimize blocking group performance and selectivityProficiency in analytical characterization: HPLC method development, LC-MS/MS for conjugate analysis, UV/Vis, and CEMethod-development mindset: history of building and adapting new chemical approaches rather than executing established protocolsDemonstrated ability to function as an independent contributor and collaborative partner in a cross-functional team setting Nice To Have: Hands-on experience with solid-phase peptide synthesis (SPPS), including protecting group strategies beyond standard Fmoc/Boc and selective on-resin modificationsExperience with peptide C-terminal chemistry manipulation methods: thioester formation, native chemical ligation, or photoredox/iridium-catalyzed C-terminal labelingFamiliarity with oligonucleotide chemistry and oligo-conjugation techniques (ITC, phosphoramidite modifications, click coupling to nucleic acids)Experience with scalable surface chemistry methods for flow cells or solid-phase supportsFamiliarity with statistical and DOE-based experimental design for chemistry optimizationPrior experience in an early-stage biotech or tools/diagnostics company We’re Looking For a Teammate That: Navigates complex team dynamics, partnerships, and challenges with creativity and logic.Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.Treats obstacles as problems to be creatively solved, not reasons something can’t be done.Applies sound judgment to the best available information, testing, learning, and iterating.Shares early and directly when assumptions change, results are unclear, or timelines are at risk. Work Environment: Collaborative culture where your ideas and expertise are valuedDirect impact on product development and company direction Professional Growth: Learn from a diverse team of world-class scientists and engineersContribute to first-of-their kind technologies, high-impact publications, and patents Benefits And Perks: Employee Stock Option Plan100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)Employer Retirement Contributions to 401(k)Generous Paid Time OffPaid Maternity and Paternity LeaveHealth & Wellbeing ProgramOffice Snacks and BeveragesRegular Team Bonding Activities We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. 244 results found No results found Afghanistan+93Åland Islands+358Albania+355Algeria+213American Samoa+1Andorra+376Angola+244Anguilla+1Antigua & Barbuda+1Argentina+54Armenia+374Aruba+297Ascension Island+247Australia+61Austria+43Azerbaijan+994Bahamas+1Bahrain+973Bangladesh+880Barbados+1Belarus+375Belgium+32Belize+501Benin+229Bermuda+1Bhutan+975Bolivia+591Bosnia & Herzegovina+387Botswana+267Brazil+55British Indian Ocean Territory+246British Virgin Islands+1Brunei+673Bulgaria+359Burkina Faso+226Burundi+257Cambodia+855Cameroon+237Canada+1Cape Verde+238Caribbean Netherlands+599Cayman Islands+1Central African Republic+236Chad+235Chile+56China+86Christmas Island+61Cocos (Keeling) Islands+61Colombia+57Comoros+269Congo - Brazzaville+242Congo - Kinshasa+243Cook Islands+682Costa Rica+506Côte d’Ivoire+225Croatia+385Cuba+53Curaçao+599Cyprus+357Czechia+420Denmark+45Djibouti+253Dominica+1Dominican Republic+1Ecuador+593Egypt+20El Salvador+503Equatorial Guinea+240Eritrea+291Estonia+372Eswatini+268Ethiopia+251Falkland Islands+500Faroe Islands+298Fiji+679Finland+358France+33French Guiana+594French Polynesia+689Gabon+241Gambia+220Georgia+995Germany+49Ghana+233Gibraltar+350Greece+30Greenland+299Grenada+1Guadeloupe+590Guam+1Guatemala+502Guernsey+44Guinea+224Guinea-Bissau+245Guyana+592Haiti+509Honduras+504Hong Kong SAR China+852Hungary+36Iceland+354India+91Indonesia+62Iran+98Iraq+964Ireland+353Isle of Man+44Israel+972Italy+39Jamaica+1Japan+81Jersey+44Jordan+962Kazakhstan+7Kenya+254Kiribati+686Kosovo+383Kuwait+965Kyrgyzstan+996Laos+856Latvia+371Lebanon+961Lesotho+266Liberia+231Libya+218Liechtenstein+423Lithuania+370Luxembourg+352Macao SAR China+853Madagascar+261Malawi+265Malaysia+60Maldives+960Mali+223Malta+356Marshall Islands+692Martinique+596Mauritania+222Mauritius+230Mayotte+262Mexico+52Micronesia+691Moldova+373Monaco+377Mongolia+976Montenegro+382Montserrat+1Morocco+212Mozambique+258Myanmar (Burma)+95Namibia+264Nauru+674Nepal+977Netherlands+31New Caledonia+687New Zealand+64Nicaragua+505Niger+227Nigeria+234Niue+683Norfolk Island+672North Korea+850North Macedonia+389Northern Mariana Islands+1Norway+47Oman+968Pakistan+92Palau+680Palestinian Territories+970Panama+507Papua New Guinea+675Paraguay+595Peru+51Philippines+63Poland+48Portugal+351Puerto Rico+1Qatar+974Réunion+262Romania+40Russia+7Rwanda+250Samoa+685San Marino+378São Tomé & Príncipe+239Saudi Arabia+966Senegal+221Serbia+381Seychelles+248Sierra Leone+232Singapore+65Sint Maarten+1Slovakia+421Slovenia+386Solomon Islands+677Somalia+252South Africa+27South Korea+82South Sudan+211Spain+34Sri Lanka+94St. Barthélemy+590St. Helena+290St. Kitts & Nevis+1St. Lucia+1St. Martin+590St. Pierre & Miquelon+508St. Vincent & Grenadines+1Sudan+249Suriname+597Svalbard & Jan Mayen+47Sweden+46Switzerland+41Syria+963Taiwan+886Tajikistan+992Tanzania+255Thailand+66Timor-Leste+670Togo+228Tokelau+690Tonga+676Trinidad & Tobago+1Tunisia+216Turkey+90Turkmenistan+993Turks & Caicos Islands+1Tuvalu+688U.S. Virgin Islands+1Uganda+256Ukraine+380United Arab Emirates+971United Kingdom+44United States+1Uruguay+598Uzbekistan+998Vanuatu+678Vatican City+39Venezuela+58Vietnam+84Wallis & Futuna+681Western Sahara+212Yemen+967Zambia+260Zimbabwe+263