Staff Scientist - Integrative Genomics Core

Job Summary

The Beckman Research Institute of City of Hope seeks a Staff Scientist to lead integrative genomics research. This position will focus on developing, optimizing, and executing advanced genomics workflows, collaborating with investigators, and contributing to the strategic growth of the core.

About the Role

The Integrative Genomics Core at City of Hope is a leading provider of genomics services that support cutting-edge biomedical research. It leverages advanced platforms like Illumina, PacBio, Nanopore, and 10x Genomics to enable a wide range of genomic and epigenomic applications, including cancer genomics and precision medicine studies.

Responsibilities

• Provide design and consultation on genomic approaches with investigators, including study design, sample requirements, and technology selection
• Complete complex genomics workflows such as bulk, single-cell, and long-read sequencing applications
• Develop, optimize, and update current protocols for Illumina, PacBio, Nanopore, and 10x Genomics platforms
• Evaluate and implement emerging technologies to expand core capabilities
• Ensure quality control standards and best practices across all stages of sample processing and sequencing
• Communicate results to investigators; collaborate with bioinformatics teams on data analysis as needed
• Aid in grant applications, methods development, and collaborative publications where appropriate
• Train, mentor, and provide technical guidance to research staff and junior personnel

Requirements

• Ph.D. in Genomics, Molecular Biology, Genetics, or a related field
• Minimum 3-5 years’ experience in genomics or sequencing technologies
• Extensive hands-on experience across multiple sequencing platforms, including Illumina, PacBio, and 10x Genomics
• Expertise in library preparation for a variety of applications (RNA-seq, DNA-seq, ATAC-seq, ChIP-seq/CUT&RUN, methylation assays, and long-read sequencing)
• Strong understanding of genomics applications, including transcriptomics, epigenomics, and variant analysis
• Experience working in a core facility or shared resource environment with a strong service orientation
• Demonstrated ability to troubleshoot complex experimental issues and improve workflow efficiency
• Strong mentoring and training experience for junior staff in laboratory techniques and best practices
• Excellent communication skills with experience consulting with investigators on experimental design and sample requirements
• Experience supporting collaborative research projects and contributing to methods sections of manuscripts or grants

Qualifications

• Ph.D. in Genomics, Molecular Biology, Genetics, or a related field
• Minimum 3-5 years’ experience in genomics or sequencing technologies
• Extensive hands-on experience across multiple sequencing platforms, including Illumina, PacBio, and 10x Genomics
• Expertise in library preparation for a variety of applications (RNA-seq, DNA-seq, ATAC-seq, ChIP-seq/CUT&RUN, methylation assays, and long-read sequencing)
• Strong understanding of genomics applications, including transcriptomics, epigenomics, and variant analysis
• Experience working in a core facility or shared resource environment with a strong service orientation
• Demonstrated ability to troubleshoot complex experimental issues and improve workflow efficiency
• Strong mentoring and training experience for junior staff in laboratory techniques and best practices
• Excellent communication skills with experience consulting with investigators on experimental design and sample requirements
• Experience supporting collaborative research projects and contributing to methods sections of manuscripts or grants

Benefits

Pay is based on experience, qualifications, and location. City of Hope is an equal opportunity employer.