Staff Mechanical Engineer, Consumables

What if your next design project wasn't just on new technology like a phone or domestic appliance but actually helped make cancer a thing of the past? At 10x Genomics, our mission is to accelerate the mastery of biology to advance human health. But that progress doesn't happen in a vacuum—it is driven by new technologies and the people with the courage to build them. We are moving with incredible urgency. We recently celebrated a massive milestone with the official unveiling of our newest innovation: Atera. This system brings high-impact single cell analysis to more researchers than ever before. To keep this momentum going, we are looking for a Staff Mechanical Engineer, Consumables who thrives on interdisciplinary collaboration and solving the intricate challenges that stand between us and the next medical breakthrough.

About the role

You’ll work alongside world-class scientists and manufacturing experts to ensure our consumables integrate perfectly with the biological workflows that are changing the world. Whether you are optimizing high-volume injection molding or leading a design from concept to commercialization, your work will be the foundation for the next generation of cures.

Responsibilities

• Strategic Design & Technical Leadership
  • Lead the architecture and design of complex biotech consumables, focusing on Injection Molded (IM) plastics, over-molding, LSR, and assembly techniques (ultrasonic welding, laser bonding).
  • Drive the development of fluidic and microfluidic systems by consulting with fluidic SMEs, ensuring seamless integration between consumable cartridges and permanent instrument hardware.
  • Utilize FEA, tolerance analysis, and CFD to predict part behavior and ensure robust performance under laboratory operating conditions.
  • Design for compliance with ISO 13485, FDA 21 CFR Part 820, and RUO. Contribute to the creation of Design History Files (DHF).
• End-to-End Project Ownership
  • Take full ownership of critical subsystems from "napkin sketch" through high-volume manufacturing (HVM).
  • Champion Design for Manufacturing (DFM) and Design for Assembly (DFA), working closely with toolmakers and CMOs to optimize tool designs and strategies.
  • Act as the primary technical point of contact for external molding partners and material suppliers, ensuring quality and performance standards are met.
• Innovation & Problem Solving
  • Identify and pursue patentable innovations in fluid handling, sealing technologies, and consumable-to-instrument interfaces.
  • Lead complex failure analysis (FEA, SEM, etc.) for plastic components, identifying issues like creep, stress cracking, or biocompatibility failures and implementing permanent corrective actions.
• Leadership & Mentorship
  • Directly mentor junior Engineers, fostering a culture of rigorous engineering discipline and creative problem-solving.
  • Serve as the "mechanical voice" in cross-functional teams with Biologists, Chemists, and Software Engineers to ensure hardware meets the underlying science.

Requirements

• BS/MS in Mechanical Engineering.
• 10+ years of experience in mechanical design, with at least 5 years specifically in medical devices or biotech consumables.
• Deep knowledge of thermoplastic resins (COC, COP, PC, PP), elastomers (TPE/TPU), and the nuances of high-volume injection molding.
• Experience with CAD (SolidWorks/Creo), PDM systems, and simulation suites.
• Familiarity with Risk Management (ISO 14971), FMEA, and Gage R&R.

Pay

Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience. This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program.

Pay Range: $179,300—$242,500 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world. We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience. Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment.