Sr. Scientist, Radiopharmaceutical Development

About the role

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients.

Responsibilities

• Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards.
• Lead the transfer of advanced radiopharmaceutical processes and technologies to internal and external manufacturing sites, including the Indianapolis facility and CDMO partners.
• Oversee the development, operation, and maintenance of radiochemistry laboratory infrastructure, ensuring readiness for translational activities from preclinical through clinical phases.
• Foster collaborative relationships with discovery scientists, external academic partners, and CDMOs to address complex scientific questions and pursue joint research efforts.
• Independently design and execute advanced radiochemistry and radiolabeling experiments, with a special focus on novel radioisotope and chelator development to enable new classes of radiopharmaceuticals.
• Serve as a subject matter expert in radiopharmaceutical production processes, quality control, and advanced analytical methodologies. Provide scientific leadership across multidisciplinary teams.
• Ensure strict adherence to radiation safety protocols, federal and state regulations, and internal guidelines for handling radioactive materials; promote a culture of safety-first and regulatory compliance.
• Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings in technical reports, regulatory documentation, and presentations for internal and external stakeholders.
• Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates.
• Draft and review CMC sections for regulatory submissions, SOPs, and comprehensive development reports.
• Travel: Less than 10% travel required, including external research sites and manufacturing facilities.

Requirements

• BSc +8, MSc + 6 years or PhD +3 years in Chemistry, Radiochemistry, Pharmaceutical Sciences, or related field with relevant industry experience, including significant CMC work with radiopharmaceutical products.
• Experience in radiopharmaceutical companies leading technology transfers to internal manufacturing or external CDMO partners for Phase 1 clinical programs strongly preferred.
• Demonstrated expertise in radiochemical synthesis, purification, formulation, and analytical techniques.
• Proven track record of innovation in radiopharmaceutical development.
• Deep familiarity with federal and state regulatory requirements and safety protocols for radioactive materials.

Qualifications

• Advanced experience developing stable radiopharmaceutical formulations with targeted attributes such as extended shelf-life, radiochemical purity, and enhanced bio-distribution.
• Hands-on expertise with commercial and custom radiopharmaceutical manufacturing and analytical equipment systems, including automation platforms, radioHPLC, radioTLC, gamma counters, dose calibrators, hot cell manipulators, and advanced gamma spectroscopy.
• Extensive experience with a broad spectrum of radioactive materials for both diagnostic and therapeutic applications.
• Strong professional ethics, integrity, and ability to maintain confidential information.
• Outstanding written and verbal communication skills, with the ability to influence and communicate effectively across all levels, including executive leadership.
• Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment.
• Demonstrated ability to manage complex research projects and mentor junior staff.

Skills

• Advanced experience developing stable radiopharmaceutical formulations with targeted attributes such as extended shelf-life, radiochemical purity, and enhanced bio-distribution.
• Hands-on expertise with commercial and custom radiopharmaceutical manufacturing and analytical equipment systems, including automation platforms, radioHPLC, radioTLC, gamma counters, dose calibrators, hot cell manipulators, and advanced gamma spectroscopy.
• Extensive experience with a broad spectrum of radioactive materials for both diagnostic and therapeutic applications.
• Strong professional ethics, integrity, and ability to maintain confidential information.
• Outstanding written and verbal communication skills, with the ability to influence and communicate effectively across all levels, including executive leadership.
• Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment.
• Demonstrated ability to manage complex research projects and mentor junior staff.

Pay

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job, such as required skills, where the job is performed, the employee’s work schedule, job-related knowledge, and experience.

Schedule

Less than 10% travel required, including external research sites and manufacturing facilities.