Sr. Scientist, Radiopharmaceutical Development

About the role

As a Sr. Scientist, Radiopharmaceutical Development at RayzeBio, you will play a pivotal role in the design, development, and advancement of transformative radiopharmaceutical therapies. Your expertise will drive the translation of cutting-edge scientific discoveries into robust clinical drug products and ensure the successful transfer of advanced radiopharmaceutical processes to internal and external manufacturing sites.

Responsibilities

• Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards.
• Lead the transfer of advanced radiopharmaceutical processes and technologies to internal and external manufacturing sites, including the Indianapolis facility and CDMO partners.
• Oversee the development, operation, and maintenance of radiochemistry laboratory infrastructure, ensuring readiness for translational activities from preclinical through clinical phases.
• Foster collaborative relationships with discovery scientists, external academic partners, and CDMOs to address complex scientific questions and pursue joint research efforts.
• Independently design and execute advanced radiochemistry and radiolabeling experiments, focusing on novel radioisotope and chelator development to enable new classes of radiopharmaceuticals.
• Serve as a subject matter expert in radiopharmaceutical production processes, quality control, and advanced analytical methodologies. Provide scientific leadership across multidisciplinary teams.
• Ensure strict adherence to radiation safety protocols, federal and state regulations, and internal guidelines for handling radioactive materials; promote a culture of safety-first and regulatory compliance.
• Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings in technical reports, regulatory documentation, and presentations for internal and external stakeholders.
• Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates.
• Draft and review CMC sections for regulatory submissions, SOPs, and comprehensive development reports.

Requirements

• BSc +8, MSc + 6 years or PhD +3 years in Chemistry, Radiochemistry, Pharmaceutical Sciences, or related field with relevant industry experience, including significant CMC work with radiopharmaceutical products.
• Experience in radiopharmaceutical companies leading technology transfers to internal manufacturing or external CDMO partners for Phase 1 clinical programs strongly preferred.
• Advanced experience developing stable radiopharmaceutical formulations with targeted attributes such as extended shelf-life, radiochemical purity, and enhanced bio-distribution.
• Extensive experience with a broad spectrum of radioactive materials for both diagnostic and therapeutic applications.
• Strong professional ethics, integrity, and ability to maintain confidential information.
• Outstanding written and verbal communication skills, with the ability to influence and communicate effectively across all levels, including executive leadership.
• Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment.
• Demonstrated ability to manage complex research projects and mentor junior staff.

Qualifications

• Advanced experience developing stable radiopharmaceutical formulations with targeted attributes such as extended shelf-life, radiochemical purity, and enhanced bio-distribution.
• Hands-on expertise with commercial and custom radiopharmaceutical manufacturing and analytical equipment systems, including automation platforms, radioHPLC, radioTLC, gamma counters, dose calibrators, hot cell manipulators, and advanced gamma spectroscopy.
• Extensive experience with a broad spectrum of radioactive materials for both diagnostic and therapeutic applications.
• Strong professional ethics, integrity, and ability to maintain confidential information.
• Outstanding written and verbal communication skills, with the ability to influence and communicate effectively across all levels, including executive leadership.
• Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment.
• Demonstrated ability to manage complex research projects and mentor junior staff.

Skills

• Advanced experience developing stable radiopharmaceutical formulations with targeted attributes such as extended shelf-life, radiochemical purity, and enhanced bio-distribution.
• Hands-on expertise with commercial and custom radiopharmaceutical manufacturing and analytical equipment systems, including automation platforms, radioHPLC, radioTLC, gamma counters, dose calibrators, hot cell manipulators, and advanced gamma spectroscopy.
• Extensive experience with a broad spectrum of radioactive materials for both diagnostic and therapeutic applications.
• Strong professional ethics, integrity, and ability to maintain confidential information.
• Outstanding written and verbal communication skills, with the ability to influence and communicate effectively across all levels, including executive leadership.
• Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment.
• Demonstrated ability to manage complex research projects and mentor junior staff.

Benefits

RayzeBio offers a comprehensive benefits package including Health Coverage, wellbeing support programs, financial well-being and protection, and work-life benefits. For more details, visit https://careers.bms.com/life-at-bms/.

Pay

$131,028 - $158,775

Schedule

Less than 10% travel required, including external research sites and manufacturing facilities.