Sr Scientist, Antibody Discovery

About the role

This is an individual contributor role that provides support for bioanalytical characterization for a variety of assays critical for characterizing therapeutic antibody candidates. This role will work closely with our Antibody Characterization and Protein Analytics team at our Quincy, MA location and is responsible for analyzing, optimizing, and troubleshooting a range of workflows, including SPR and BLI affinity analysis, developability assays, flow cytometry, functional assays, and target binding characterization.

Responsibilities

• Guide multiple projects per day to ensure scientific excellence and execution for antibody projects involving binding affinity determination (SPR, BLI) and developability assays (i.e. aSEC, CIC, HIC, BVP-ELISA, AC-SINS, plate-based off-target assays, DLS, and nanoDSF) for a variety of antibody and biologics formats (IgG, VHH, Minibinders, etc.)
• Assist cross-functionally with the wet lab teams, Project Management team and scientific leaders across multiple sites within the company to ensure exquisite execution of individual projects, while also providing guidance for future assay integration and improvement in the antibody discovery workflow.
• Provide technical guidance (assay development, analysis, and data reporting) for antibody-based projects in a range of areas, including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), developability assays, advanced/custom characterization, and functional screening.
• Serve as an end-to-end technical lead for a variety of in vivo antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping.
• Review, critically analyze, and present data to customers for a variety of concurrent antibody discovery programs.
• Work closely with the Project Management team to communicate timelines and deliverables to internal and external stakeholders and customers.
• Spend time performing wet-lab benchwork alongside the team based on workflow and assay development needs. It is anticipated that the role would involve an 80/20 split of analysis vs wet lab time.

Qualifications

• PhD in a related technical field with 5+ years of experience in biopharmaceutical analytical development or master's in a related technical field with 10+ years of experience
• Expert knowledge of antibody biologics characterization assays: extensive hands-on experience required in Carterra SPR, Octet BLI, ELISA, flow cytometry, and antibody developability characterization.
• Advanced understanding of in vivo antibody discovery concepts.
• Strong track record of developing, executing, and analyzing common assay formats for antibody discovery, such as high-throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and cell-based functional assays.
• Demonstrated capability to work autonomously, prioritizing responsibilities within a high-pressure setting characterized by concurrent projects and time-critical workflows.
• Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics.
• Exceptional written and verbal communication skills, including external customer-facing communication.
• Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics.

Benefits

Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

Pay

Massachusetts Pay Range
$131,000 - $142,600 USD

Schedule

Onsite in Quincy, MA