Sr. Research Associate

About the role

Senior Research Associate. As a hands-on molecular biology expert, you will play a key role in advancing Dyno’s animal studies to identify and develop cutting-edge muscle AAV-based capsids. You will process and analyze tissues from in vivo studies, support histology workflows, and conduct in vitro experiments to characterize leading capsids and capsid libraries. Working closely with Research Associates, Scientists, and Computational Biologists, you will help the Muscle team generate high-quality data that shapes the future of gene therapy. As a Senior Research Associate, you will provide hands-on experimental support across tissue processing, molecular measurements, histology, and in vitro characterization. You will work alongside a team of talented scientists and contribute to a diverse range of projects. Your role will require you to optimize workflows, troubleshoot problems, and ensure successful project outcomes by aligning with team goals. At Dyno, every role is mission-driven. Whether in science, engineering, operations, or business, each AAViator contributes to solving some of the most complex challenges in genetic medicine. At Dyno Therapeutics, we are a high-energy, high-impact team on a mission to build high-performance genetic technologies that transform patient lives. Our team unites world-class molecular biologists, protein engineers, software developers, data scientists, and machine learning experts—all working together at the intersection of AI and genetic medicine.

Responsibilities

• Sample inventory and dissection of tissues (mammalian cells, non-human primate and mouse tissues).
• Extract, purify, and enrich nucleic acids from mammalian cells and tissues.
• Run quantification assays on purified nucleic acids (e.g., qPCR, RT-qPCR).
• Prepare next-generation sequencing libraries (amplicon sequencing) and perform associated QC steps.
• Support histology workflows, including tissue preparation, sectioning, staining, imaging, and analysis.
• Maintain mammalian cell cultures and execute cell-based experiments to characterize leading muscle capsids and capsid libraries.
• Analyze experimental data, identify technical issues, and recommend appropriate next steps in collaboration with project leads.
• Maintain detailed and accurate records of samples, experimental procedures, and results using Dyno’s electronic laboratory notebook and LIMS systems.
• Communicate findings clearly and collaborate across experimental and computational teams to achieve project goals.
• Adhere to lab protocols and safety regulations to ensure a safe working environment.
• Work with urgency and adaptability, balancing innovation with execution.
• Collaborate cross-functionally, leveraging Dyno’s high-trust, high-impact culture to drive results.

Requirements

• BS or MS in biology, biochemistry, biomedical engineering, or related fields.
• At least 3 years of full time, post graduate, hands-on wet lab experience.
• Experience in DNA/RNA purification and analysis protocols (qPCR, RT-qPCR, etc.).
• Experience handling mammalian tissues or other complex biological samples.
• Ability to execute complex protocols with high accuracy,