SR. RESEARCH ASSOCIATE/ASSOCIATE SCIENTIST, NONCLINICAL DEVELOPMENT

Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients.

Responsibilities

• Coordinate and execute in vivo and ex vivo nonclinical studies to evaluate Adicet’s immune-cell and gene-therapy platforms, including efficacy, pharmacokinetic/pharmacodynamic, and safety assessments in relevant murine oncology and immunology models.
• Contribute to study design, experimental planning, timeline development, and data-driven decision-making to support program advancement.
• Collaborate and communicate effectively with cross-functional teams and external contract research organizations to coordinate study execution, troubleshoot technical challenges, and ensure study endpoints align with program objectives.
• Perform necropsies and process tissues for downstream analyses, including flow cytometry, qPCR/ddPCR, and ELISA, to characterize pharmacologic activity and elucidate mechanisms of action.
• Maintain accurate, complete, and well-organized experimental records in accordance with internal documentation and quality standards.

Requirements

• Bachelor’s degree in biological sciences or a related field with 5+ years of relevant R&D experience, or a Master’s degree with 3+ years of experience, preferably in immuno-oncology, within an industry setting.
• Significant experience designing, executing, analyzing, and interpreting in vivo studies using murine xenograft disease models and/or humanized immunology models.
• Demonstrated proficiency administering therapeutic agents and establishing xenograft models through intravenous, intraperitoneal, and subcutaneous routes in mice.
• Strong technical proficiency in blood collection, including submandibular and tail-vein sampling, as well as tissue necropsy and sample processing for flow-cytometry applications.
• Experience with aseptic mammalian cell culture, including the maintenance and preparation of human cancer cell lines for nonclinical in vivo studies.
• Hands-on experience with in vivo bioluminescence and/or fluorescence imaging, including image acquisition and data analysis using IVIS platforms.
• Experience with laboratory techniques such as flow cytometry, ELISA, qPCR/ddPCR, and cytokine bead-based assays is preferred.
• Excellent organizational, communication, data-analysis, and technical-documentation skills.
• Demonstrated ability to work independently, troubleshoot scientific and technical challenges, and contribute innovative solutions.
• Ability to manage multiple priorities and thrive in a fast-paced, collaborative, and supportive research environment.

Schedule

Employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.

Pay

Pay Range $108,000 - $150,000 USD

Benefits

• Competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match.
• Comprehensive health plans (medical, dental, vision, etc.).
• Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA).
• Life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs.
• Generous paid time-off including 13 company holidays, paid end-of-year winter break, vacation, sick time, and paid parental leave.
• Onsite gym and various other fitness options.
• Onsite parking with electric vehicle charging stations and free shuttle (Caltrain).
• Company-subsidized lunches (delivered onsite daily) and fully stocked breakrooms.