Sr Computational Research Scientist- MA's Lab

About the role

The Ma laboratory in the Department of Computational Biology is seeking an experienced Senior Computational Research Scientist for the Pediatric Cancer Dependency (PedDep) project, a joint initiative between St. Jude, Dana Farber Cancer Institute, and the Broad Institute. With vast knowledge accumulated from patient tumor data, we are now characterizing cell models (cell lines and PDX models) for childhood cancers to discover novel vulnerabilities that can lead to new therapeutic targets.

Responsibilities

• Lead computationally focused scientific research projects with little supervision from their PI.
• Initiate and execute research strategies in partnership with the Principal Investigator, collaborator, and/or more experienced scientists.
• Explore, identify, and propose adoption of relevant emerging scientific and technical trends in computational research; develop new methods, techniques, and procedures.
• Identify, process, organize, interpret, review, and report relevant data; generate hypotheses to predict future implications based on the critical evaluation of these data.
• Direct/monitor data collection.
• Present research both internally and externally to multi-disciplinary audiences; draft complex manuscripts.
• Provide ongoing instruction and guidance to junior-level staff and train as needed.
• Perform other duties as assigned to meet the goals and objectives of the department and institution.
• Maintain regular and predictable attendance.

Requirements

Training in Bioinformatics, Molecular Biology, Computer Science, or related fields. Bachelor's degree and 7+ years of relevant experience. Experience Exception: Master's degree and 5+ years of relevant experience (OR) PhD with 2+ years of relevant experience. Substantial experience in own technical area including advanced research techniques. Experience leading complex research studies in a technical capacity preferred. Experience training and guiding early-career researchers preferred. Proven performance in earlier role/ comparable role.

Qualifications

Highest degree is PhD, MD, or equivalent combination of education and experience.

Skills, Knowledge, and Abilities

• Strong knowledge in molecular biology, genetics, genomics and statistics.
• Next generation sequencing: variant calling; IGV-based variant inspection; whole-genome/exome analysis for mutations including copy number, loss of heterozygosity, structural variation, SNV/Indel; RNAseq based fusion analysis; bam/fastq operations including mapping and basic quality control; variant functional interpretation using data collected from patient cohort and molecular biology and genetics principles.
• Programming: [Python or Perl or C/C++] and R.
• Operating system: High performance computing system, bash scripting.
• Office: Microsoft Excel/Word/PowerPoint.
• Preferred: Adobe Illustrator (no Photoshop).

Special Skills, Knowledge, and Abilities

• Scientifically curious, rigorous, and capable of working independently.
• Experience in own technical area including advanced research techniques.
• Experience leading complex research studies in a technical capacity preferred.
• Experience training and guiding early-career researchers preferred.
• Proven performance in earlier role/ comparable role.
• Strong knowledge in molecular biology, genetics, genomics and statistics.
• Next generation sequencing: variant calling; IGV-based variant inspection; whole-genome/exome analysis for mutations including copy number, loss of heterozygosity, structural variation, SNV/Indel; RNAseq based fusion analysis; bam/fastq operations including mapping and basic quality control; variant functional interpretation using data collected from patient cohort and molecular biology and genetics principles.
• Programming: [Python or Perl or C/C++] and R.
• Operating system: High performance computing system, bash scripting.
• Office: Microsoft Excel/Word/PowerPoint.
• Preferred: Adobe Illustrator (no Photoshop).

Benefits

Explore our exceptional benefits!

Pay

A reasonable estimate of the current salary range is $104,000 - $186,160 per year for the role of Sr Computational Research Scientist- MA's Lab.

Schedule

N/A