Sr Associate Scientist, Biology

About the role

Gilead Sciences is seeking a skilled Sr. Associate Scientist to support pharmacokinetic (PK) bioanalysis of large molecules across discovery and early development programs. This individual will play a key role in independently developing, executing, and troubleshooting high throughput bioanalytical assays, while collaborating closely with cross-functional teams to deliver high-quality data that informs critical project decisions.

Key Responsibilities

• Design, develop, and execute bioanalytical assays for large molecules and ADCs
• Perform ligand-binding assays (LBA) such as ELISA and MSD in different biological matrices to support PK studies
• Independently analyze and interpret experimental data, and ensure data quality and integrity
• Independently troubleshoot assay performance issues and implement effective solutions
• Manage PK sample analysis workflows across multiple studies
• Collaborate with DMPK, biology, and project teams
• Prepare presentations and written reports
• Maintain accurate documentation
• Contribute to automation and workflow improvements
• Support broader discovery and screening activities

Required Qualifications

• BS with 5+ years or MS with 3+ years in Pharmaceutical Science, Biochemistry, Biology or related discipline
• 2–3 years of industry experience in PK bioanalysis, DMPK, or related field
• Hands-on experience independently supporting and executing in vivo PK studies for large molecules (e.g., monoclonal antibodies, peptides, biologics)
• Expertise in ligand-binding assays (ELISA, MSD, Gyrolab), including assay development, optimization, and troubleshooting
• Broad knowledge of PK bioanalytical assays, including ADCD
• Demonstrated ability to analyze and interpret PK data, including curve fitting (4PL/5PL), QC evaluation, and trend analysis
• Strong understanding of PK/ADME principles for biologics (AUC, clearance, half-life, TMDD, nonlinear PK)
• Working knowledge of antibody-drug conjugates (ADCs) and their bioanalytical challenges
• Proven ability to design experiments and troubleshoot independently
• Ability to manage multiple studies and timelines
• Strong communication and presentation skills

Preferred Qualifications

• Experience with LC-MS/MS
• Familiarity with HTS (96/384/1536-well formats) and laboratory automation

Pay

The salary range for this position is: $126,820.00 - $164,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary.