Senior Scientist, Target Discovery & Biology - Functional Genomics

Join Amgen’s mission of serving patients. At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With a focus on four therapeutic areas—Oncology, Inflammation, General Medicine, and Rare Disease—we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.

About the role

In this vital role, you will join the Target Discovery & Biology team in South San Francisco. This role will leverage functional genomics in disease-relevant systems, including complex biological models from in vitro to in vivo, to advance target discovery and validation across Amgen’s therapeutic areas.

Responsibilities

• Leverage functional genomics approaches across therapeutic areas to discover novel targets and address key biological questions
• Lead, support, and execute projects from inception through target identification, validation, and mechanism-of-action studies
• Foster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgen’s pipeline

Qualifications

Basic Qualifications

• Doctorate degree (PhD, PharmD, or MD) and relevant post-doc scientific experience in Target Discovery & Biology
• Master’s degree and 3 years of relevant scientific experience in Target Discovery & Biology
• Bachelor’s degree and 5 years of relevant scientific experience in Target Discovery & Biology

Preferred Qualifications

• Strong experience in molecular biology and cell engineering; experience in complex and co-culture in vitro models is a major plus
• Experience in executing large-scale, complex, and/or in vivo genetic screens (particularly CRISPR-based) and follow-up validation studies; track record of pushing the envelope on scale and technical feasibility is highly desirable
• Familiarity with data-driven discovery approaches, including integration of genetic or multi-omics insights
• Excellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environment
• Additional experience relevant to applying functional genomics approaches to new target discovery across diverse indications
• Track record of scientific productivity and innovation as demonstrated through career experiences, project outcomes, and/or publications
• Track record of taking on new areas of research and biology with successful outcomes

Benefits

From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible

Sponsorship for this role is not guaranteed.