Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

About the role

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission to serve patients living with serious illnesses drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease, we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives.

Responsibilities

• Independently and collaboratively conduct bioanalysis of siRNA therapeutics in preclinical samples (in vitro and in vivo)
• Work independently and in teams to establish innovative in vitro ADME assays for characterizing siRNA mechanism of action and generate high-quality, mechanistic insights to support discovery programs
• Work independently and in teams to design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of siRNA therapeutics
• Build strong interdepartmental relationships and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept

Requirements

• Doctorate degree [and relevant post-doc where applicable] in pharmacology, biochemistry or a related-scientific discipline
• Or Masters degree in pharmacology, biochemistry or a related-scientific discipline and 3 years of industry experience
• Or Bachelors degree in pharmacology, biochemistry or a related-scientific discipline and 6 years of industry experience

Qualifications

• Extensive knowledge of siRNA therapeutics, particularly within the context of ADME and pharmacokinetics
• Proven experience in designing and executing fit-for-purpose mechanistic assays to address key scientific questions related to siRNA therapeutics
• Hands-on experience with ligand binding assays (specifically immunoassay and hybridization assays), LC/MS bioanalytical platforms, and nucleic acid quantification techniques (RT-qPCR or RT-ddPCR)
• Strong critical thinking, problem-solving, and data interpretation skills
• Excellent written and verbal communication skills

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Schedule

Full time