Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

About the role

Join Amgen’s mission to serve patients living with serious illnesses. In this role, you will contribute to the Pharmacokinetics & Drug Metabolism – Bioanalytical Sciences (PKDM-BA) team, advancing Amgen’s growing siRNA research portfolio. You will develop and execute innovative bioanalytical platforms to measure siRNA in preclinical samples, both in vitro and in vivo, to characterize ADME, pharmacokinetics, and pharmacokinetic-pharmacodynamic relationships. Additionally, you will design and perform mechanistic studies to support siRNA discovery research programs, clinical candidate selection, and regulatory applications.

Responsibilities

• Independently and collaboratively conduct bioanalysis of siRNA therapeutics in preclinical samples (in vitro and in vivo).
• Establish innovative in vitro ADME assays for characterizing siRNA mechanism of action and generate high-quality, mechanistic insights to support discovery programs.
• Design, execute, and interpret results from in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics of siRNA therapeutics.
• Build strong interdepartmental relationships and foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept.

Qualifications

Basic Qualifications

• Doctorate degree (and relevant post-doc where applicable) in pharmacology, biochemistry, or a related scientific discipline.
• Or Master’s degree in pharmacology, biochemistry, or a related scientific discipline and 3 years of industry experience.
• Or Bachelor’s degree in pharmacology, biochemistry, or a related scientific discipline and 6 years of industry experience.

Preferred Qualifications

• Extensive knowledge of siRNA therapeutics, particularly within the context of ADME and pharmacokinetics.
• Proven experience in designing and executing “fit-for-purpose” mechanistic assays to address key scientific questions related to siRNA therapeutics.
• Hands-on experience with ligand binding assays (specifically immunoassay and hybridization assays), LC/MS bioanalytical platforms, and nucleic acid quantification techniques (RT-qPCR or RT-ddPCR).
• Strong critical thinking, problem-solving, and data interpretation skills.
• Excellent written and verbal communication skills.

Benefits

Amgen supports your professional and personal growth with a competitive benefits package, including:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental, and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models where possible.

Pay

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted on the careers site. Actual salary will vary based on relevant skills, experience, and qualifications.