Senior Scientist, Safety Assessment

Primary Responsibilities

• Contribute to nonclinical safety activities as part of cross-functional Discovery and Development project teams, supporting program progression through IND-enabling stages.
• Design, execute, and troubleshoot nonclinical safety studies, including hands-on laboratory work (~30%) to support assay development, data generation, and issue resolution.
• Support the execution and oversight of nonclinical safety studies (GLP and non-GLP) at CROs, including active involvement in troubleshooting assay and study-related challenges.
• Analyze and interpret study data with guidance and contribute to the preparation of study reports and supporting documents for regulatory submissions.
• Collaborate with Pharmacology, DMPK, and other functions to support exploratory studies (e.g., exploratory toxicology, DMPK, biodistribution, and delivery platform evaluation).
• Contribute to evaluation of new delivery approaches, Lipid and RNA components, and emerging targets to support pipeline expansion.
• Assist in identifying potential safety findings and contribute to discussions on data interpretation and next steps.
• Ensure studies and internal activities are conducted in compliance with regulatory guidelines and internal standards.

Preferred Qualifications

• Ph.D. in toxicology or a related discipline with 6+ years of biopharmaceutical industry experience, or M.S. in toxicology or a related field with 10+ years of relevant biopharmaceutical industry experience supporting drug development in nonclinical safety/toxicology.
• Experience in large molecule therapeutic development, along with a background in immunology, is desirable.
• Understanding of toxicology principles, nonclinical safety evaluation, and the drug development process, with some experience interpreting toxicology data and contributing to technical and scientific reports.
• Demonstrates strong scientific judgment and leadership with the ability to evaluate information, identify potential issues, and propose practical solutions with guidance as needed.
• Highly organized and detail-oriented with strong attention to accuracy and quality.
• Strong communication and collaboration skills, with the ability to work effectively across multidisciplinary teams and with external partners.
• Experience supporting nonclinical studies at CROs is preferred but not required.

Pay

$145,000 - $177,000 USD

Benefits

• Comprehensive Total Rewards package with robust health, financial, and wellness benefits.
• Includes medical, dental, vision, life insurance, a 401(k) match, and equity programs.
• Generous paid time off, wellness days, and company-wide recharge breaks.

About the Role

The Senior Scientist will play a critical role in supporting the nonclinical safety assessment function for IND-enabling programs across Prime Medicine’s pipeline. They will collaborate with cross-functional teams to ensure the success of nonclinical safety studies and contribute to the advancement of Prime Medicine’s therapeutic programs.