Senior Scientist, R&D Assay Development

About the role

Natera is a global leader in cell‑free DNA testing. The R&D Department is seeking a highly motivated Senior Scientist to join the rapidly growing assay development team. The role involves leading and supporting junior scientists and laboratory technicians to plan, execute, and manage scientific studies under design control in a regulated environment, contributing to the development of laboratory tests that positively impact the business and patients.

Responsibilities

• Design development, verification, and validation studies with stakeholder input and coordinate efforts to achieve milestones within established timelines.
• Collaborate closely with cross‑functional teams (automation, engineering, R&D, bioinformatics, lab operations) to develop robust, automated workflows.
• Lead integration testing of automated workflows with software LIMS systems; support design and execution of integration testing to ensure data integrity.
• Plan, execute, analyze, and present data for moderate to high‑complexity experiments, including hands‑on troubleshooting.
• Identify root causes of problems and develop effective solutions.
• Perform basic data analysis (e.g., Excel, JMP) and utilize AI agents such as Gemini and Claude.
• Coordinate analysis of studies with biostatistics and bioinformatics teams.
• Provide regular updates at project team and departmental meetings on progress, outcomes, and next steps.
• Author and review SOPs, study reports, and transfer documents for production implementation.
• Train team members on new SOPs and automated workflows.
• Support lab operations, including troubleshooting and technical guidance.
• Handle multiple tasks and priorities flexibly and perform other duties as assigned.

Qualifications

• University degree with a minimum of 8+ years of related experience, or an MS degree with 6 years, or a PhD with 4 years of related experience.
• Knowledge of high‑throughput NGS workflows or other genetic testing applications in clinical settings.
• Experience developing and validating molecular assays for CLIA lab testing.
• Experience with automation of molecular workflows or assay transfer to automated platforms.
• Experience managing responsibilities across more than one project.
• Very strong interpersonal, analytical, and problem‑solving skills.
• Proactive, solutions‑oriented mindset with demonstrated success in collaborative and individual projects.

Desired Knowledge, Skills, and Abilities

• Advanced technical proficiency in standard and long‑range PCR techniques, including primer design and optimization.
• Proficiency with NGS technologies (e.g., Illumina, PacBio), qPCR, ddPCR, and multiplex PCR.
• Knowledge of design verification/validation processes compliant with U.S. and E.U. regulatory standards.
• Exceptional communication and presentation skills with meticulous attention to detail.

Pay

Location: Austin, TX – $106,200 — $132,700 USD. Actual compensation packages are based on a wide array of factors unique to each candidate, including skill set, years & depth of experience, certifications, and specific office location.

Benefits

• Comprehensive medical, dental, vision, life, and disability plans for eligible employees and dependents.
• Free testing for employees and immediate families, plus fertility care benefits.
• Pregnancy and baby bonding leave.
• 401(k) retirement plan.
• Commuter benefits.
• Generous employee referral program.