Senior Scientist / Principal Scientist – Process Chemistry

About the role

Treeline Biosciences, a clinical-stage biotechnology company advancing precision medicines, is seeking an experienced small molecule process chemist to drive the development, scale-up, and commercial readiness of our small molecule, clinical-stage portfolio. This role centers around close collaboration with the medicinal chemistry team within the discovery portfolio. Additionally, the role is critical to ensuring clinical supply and commercial readiness for identified programs and ensuring that drug substance manufacturing processes meet quality, regulatory, safety, scalability, and scalability expectations.

Responsibilities

• Collaborate with medicinal chemistry partners to support candidate selection and developability assessments. Advise and assist with sourcing scaffolds and intermediates as appropriate.
• Design and execute route scouting and synthetic strategies for drug candidates and key intermediates.
• Design and optimize chemical transformations and scalable synthetic routes to enable efficient and robust processes for discovery and early development programs.
• Enable rapid compound synthesis and methodologies to support SAR campaigns and discovery timelines.
• Apply modern synthetic technologies to address complex synthetic challenges.
• Support multi-gram to kilogram-scale synthesis for biological and toxicology studies.
• Manage external partners and cultivate strong, collaborative relationships to support program objectives.
• Contribute to early CMC understanding, including impurity identification and process considerations.
• Communicate results through technical reports, documentation, and presentations.
• May be involved with preparations for the first GMP synthesis of a clinical candidate for Phase 1 trials.
• Able to travel up to 10% to support program needs, including on-site support at manufacturing plants and partner collaboration.

Qualifications

• Ph.D. in Organic Chemistry or related discipline with 3–8+ years of relevant industry or postdoctoral experience; M.S. with 6–10+ years of industry experience also considered.
• Strong expertise in synthetic organic chemistry, reaction development, and route design.
• Experience with complex molecule synthesis and route optimization.
• Familiarity with scale-up considerations and impurity control in chemical processes.
• Ability to work effectively within cross-functional discovery teams.
• Experience working with and managing external CDMO partners.
• Strong written and verbal communication skills.
• Strong project leadership skills with the ability to manage complex timelines, multiple stakeholders, and evolving program priorities.
• Strong communication and collaboration skills with a proven ability to work cross-functionally in a fast-paced, science-driven environment.
• High level of personal integrity, commitment to excellence and to our patients.