Senior Principal Scientist, Process Chemistry

About the role

Lead technical teams to design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale-up. Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability. Lead authorship of patents, publications, and regulatory documents. Apply modern synthetic organic chemistry principles, high-throughput experimentation, mechanistic insight, and data-rich methods to accelerate development. Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions. Drive alignment to project timelines and portfolio strategy. Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment. Lead technology transfer and partner interactions to enable external development campaigns. Build strong stakeholder relationships across process chemistry, partner functions, and project teams. Maintain an external technical presence through publications and presentations.

Responsibilities

• Lead technical teams to design, execute, and interpret complex laboratory experiments aimed at route development, process optimization, and scale-up.
• Develop fit-for-purpose processes for early- and late-stage programs, ensuring safety, robustness, and scalability.
• Lead authorship of patents, publications, and regulatory documents.
• Apply modern synthetic organic chemistry principles, high-throughput experimentation, mechanistic insight, and data-rich methods to accelerate development.
• Effectively communicate scientific strategy, risks, and solutions to project teams, leadership, and partner functions.
• Drive alignment to project timelines and portfolio strategy.
• Mentor junior staff and foster an inclusive, scientifically rigorous, and collaborative environment.
• Lead technology transfer and partner interactions to enable external development campaigns.
• Build strong stakeholder relationships across process chemistry, partner functions, and project teams.
• Maintain an external technical presence through publications and presentations.

Requirements

• PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development, including route design, scale-up, and GMP manufacturing
• Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies.
• Demonstrated scientific impact via peer-reviewed publications, patents, or conference presentations.
• Strong communication skills with demonstrated collaborative leadership in cross-functional process development teams.
• Experience supporting development from preclinical through commercial stages.
• Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.

Preferred Qualifications

• Proficient in current Good Manufacturing Practices (GMP)
• Skilled in reaction modeling, material property prediction, and simulation using advanced computational tools such as DynoChem, gPROMS, Visimix, Aspen, Fluent, and Cosmotherm
• Experience in regulatory filing and compliance
• Experience developing drug-linkers for ADCs, PROTACS, DACs or other targeted mixed-modality therapeutics
• Experience mentoring and developing scientific staff
• Experience with technology transfer and oversight of external development work
• Experience at innovator pharmaceutical companies is strongly preferred

Basics

BASIC QUALIFICATIONS: PhD in Organic Chemistry with 8+ years of industry experience in pharmaceutical process development, including route design, scale-up, and GMP manufacturing Deep foundational understanding of synthetic organic chemistry, reaction mechanisms, process development, and modern purification and analytical technologies. Demonstrated scientific impact via peer-reviewed publications, patents, or conference presentations. Strong communication skills with demonstrated collaborative leadership in cross functional process development teams. Experience supporting development from preclinical through commercial stages. Experience in regulated pharmaceutical environments including GMP operations and authoring regulatory submissions.

Pay

The annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share-based long-term incentive program.

Schedule

Work Location Assignment: On Premise Last date to apply is July 14, 2026

Benefits

We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com).

Additional Job Details

Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility.