Senior Scientist, Molecular Discovery

About the role

We are seeking a highly motivated Senior Scientist to join the Protein Sciences department within Discovery Biologics in South San Francisco. This role will focus on design and execution of molecular interactions assays to advance biologics discovery, lead optimization of next-generation biologics modalities.

Responsibilities

• Design, execute, and interpret experiments to characterize molecular interactions using SPR (Biacore) and related biosensor platforms
• Develop, optimize, and troubleshoot assays across multiple binding formats (e.g., antibody-antigen, multivalent, complex systems)
• Partner with computational and protein engineering teams to produce high-quality datasets supporting AI/ML-driven design workflows
• Contribute data to candidate evaluation, selection, and optimization decisions, as well as our structured data capture product
• Explore and implement new technologies and methods to enhance assay throughput, robustness, and data quality
• Communicate findings clearly through technical reports and presentations to project teams, departmental forums, and leadership
• Mentor junior scientists or research associates as needed and contribute to a collaborative, high-performing team environment

Qualifications

• Education: Bachelor's (with 7+ years), Master's (4+ years) or Ph.D. in molecular biology, biochemistry, structural biology or related discipline with relevant experience described below
• Required Experience And Skills:
• Demonstrated expertise in SPR/BLI and/or other biosensor technologies for analyzing molecular interactions
• Strong hands-on experience in experimental design, assay development, and troubleshooting for biophysical binding assays
• Experience characterizing proteins and/or antibodies in the context of drug discovery or protein engineering
• Solid understanding of protein structure, protein-ligand interactions, and biophysical principles
• Proven ability to analyze complex datasets and draw clear, actionable conclusions
• Proven ability to manage multiple projects and meet timelines in a fast-paced environment
• Strong collaboration and communication skills across multidisciplinary teams
• Preferred Experience And Skills:
• Experience with high-throughput or automated assay platforms and generation of structured datasets for downstream computational analysis
• Familiarity with AI/ML-enabled protein engineering workflows and data generation strategies
• Experience with complementary techniques such as FACS, Kinexa, ITC, ELISA, and Meso Scale Discovery
• Proficiency with data analysis tools, databases, and electronic lab notebooks

Why Join Us

Work at the cutting edge of biologics discovery, integrating biophysics, protein engineering, and machine learning
Contribute directly to decision-making across a diverse and innovative therapeutic pipeline
Collaborate with experts across discovery biology, computational science, and translational research
Access state-of-the-art instrumentation and emerging technologies

Requirements

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.

Requisition ID

R405899