Senior Scientist II - Translational Pathologist
MacroGenics, Inc. · Rockville, MD · 4 mo ago
On-siteHealthcare$126k–$193k/yrFull-time
Responsibilities
- Perform necropsy and primary histopathologic assessment of tissues from in vivo pharmacology studies, including H&E, IHC, and multiplex immunofluorescence.
- Conduct first-pass assessment of target expression, on-target/off-tumor findings, ADC payload-related tissue injury, and tumor-immune microenvironment features relevant to immunotherapy programs.
- Prepare draft pathology interpretations, figures, and written summaries for internal review and program discussions.
- Biomarker & Assay Support:
- Execute pathology components of translational biomarker strategies as defined by senior Pathology and Translational Medicine leadership.
- Support development, optimization, and validation of single plex IHC and multiplex IHC and IF assays.
- Perform tissue annotation and support development and optimization of digital pathology and image analysis algorithms under the guidance of the Senior Director of Pathology.
- Contribute pathology data and figures to internal reports, study summaries, and regulatory-supporting documentation.
- Carefully coordinate biomarker assay development and validation with CROs.
- Documentation & Data Stewardship:
- Draft pathology sections for study reports, slide decks, and internal presentations.
- Maintain pathology image libraries, annotations, and reference materials.
- Support development and maintenance of pathology-related SOPs, templates, and best practices.
- Cross-Functional Collaboration:
- Present pathology findings in internal project team meetings.
- Escalate and communicate complex findings, safety signals, or interpretation questions to the Translational Medicine leadership.
- Education & Experience:
- MD, DVM, or PhD with formal training in pathology, histopathology, or a closely related discipline.
- 3–5 years of experience in biomarker target validation, translational research, biotechnology, pharmaceutical, or CRO environments.
- Skills & Abilities:
- Hands-on experience with histopathologic and immunohistochemical tissue evaluation.
- Excellent pathology diagnostic skills.
- Skilled in mIF development, validation and spatial analysis.
- Experience with digital pathology and image analysis platforms (e.g., HALO, QuPath).
- Strong scientific writing and communication skills.
- Preferred Qualifications:
- MD/DVM strongly preferred.
- Experience supporting ADC, immuno-oncology, or T-cell engager programs.
- Experience working with AI/ML algorithms for digital pathology analysis.
- Exposure to GLP toxicology studies and nonclinical safety assessments.
- Experience working with external CROs.