Senior Scientist I, DMPK

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. The company focuses on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins involved in disease. Arrowhead’s RNAi technologies enable addressing conditions across virtually any therapeutic area, including disease targets not otherwise addressable by small molecules and biologics. The company leads the field in bringing RNAi therapies to diseases outside the liver, with a clinical pipeline targeting the liver and lung, and a robust preclinical pipeline. Headquartered in Pasadena, CA, Arrowhead has research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the role

Arrowhead Pharmaceuticals is seeking an accomplished Senior Scientist, DMPK to play a key role in advancing our growing pipeline of RNAi-based therapeutics. As a senior member of the Drug Metabolism and Pharmacokinetics (DMPK) function, you will partner closely with multidisciplinary teams of chemists, biologists, and translational scientists to shape strategies that enable successful candidate nomination and IND submissions. This high-impact role involves leading the design and execution of preclinical DMPK studies, guiding interpretation of complex PK/PD data, overseeing internal and external study activities, and ensuring delivery of high-quality datasets that meet regulatory expectations. The ideal candidate brings deep technical expertise, strong problem-solving skills, and the ability to thrive in a fast-paced, collaborative environment dedicated to scientific excellence and innovative drug development.

Responsibilities

• Develop and implement in vitro and in vivo DMPK strategies to support preclinical development for compounds across multiple indications and routes of administration.
• Manage all DMPK activities, including oversight of internal resources and CRO partners to ensure high-quality and timely data delivery.
• Design, supervise, and execute preclinical PK studies, including non-compartmental analysis (NCA), data interpretation, reporting, and communication of PK/PD insights to project teams.
• Prepare and deliver IND-enabling DMPK packages, ensuring compliance with regulatory expectations and contributing to regulatory submissions.
• Apply working knowledge of GLP/GCP principles and ensure appropriate documentation for regulated studies.
• Support GLP toxicokinetic (TK) study design, analysis, and reporting.
• Oversee metabolite identification in preclinical and clinical samples using high-resolution mass spectrometry (HRMS).
• Contribute to a dynamic, fast-paced DMPK team by offering scientific leadership, troubleshooting support, and cross-functional collaboration.
• Maintain a current understanding of clinical pharmacology literature and regulatory guidance for oligonucleotide/RNAi therapeutics.

Requirements

• PhD in Pharmacometrics, Drug Metabolism, Pharmaceutical Sciences, or a related discipline with at least 3 years of industry experience.
• Deep and broad expertise in DMPK, with working knowledge of nucleotide or oligonucleotide drug metabolism and distribution highly desired.
• Hands-on experience with in vitro ADME assays, in vivo PK studies, drug-drug interaction (DDI) evaluations, and Phoenix WinNonlin.
• Experience with LC-MS/MS and HRMS, ideally applied to oligonucleotide therapeutics.
• Strong background in organic chemistry, biochemistry, and drug biotransformation.
• Demonstrated experience in drug development and understanding of regulatory processes.
• Excellent interpersonal, verbal, and written communication skills, with the ability to interpret and present complex scientific data clearly.

Pay

Wisconsin pay range: $115,000–$140,000 USD

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.