Senior Scientist I

About the role

The Senior Scientist I is responsible for carrying out advanced metabolite identification and elucidation, reporting findings in the metabolism-biotransformation function. They are expected to deliver high-quality data promptly to support discovery, IND, and late-stage development work. They must perform complex troubleshooting and problem-solving in metabolism areas, implement new technologies and processes, coordinate with other functions, and manage projects.

Responsibilities

• Identify and elucidate drug metabolites using liquid chromatography-tandem high-resolution accurate mass spectrometry, NMR, and other analytical methodologies.
• Design and conduct complex in vivo and in vitro metabolism studies.
• Implement new technologies and processes.
• Coordinate and work with other functions to deliver outstanding outcomes for assays/studies/projects in drug discovery and development.
• Provide multiple approaches during the planning step.
• Work on complex problems involving intangible variables.
• Develop methods, techniques, and evaluation criteria for obtaining results.
• Handle radio-labeled materials (e.g., 3H, 14C).
• Function as a study director, principal investigator, or project manager.
• Conduct and deliver projects in high quality and time fashion.
• Review other scientists' calculations, records, and reports.
• Train, coach, or mentor others on technical, personal development, or business issues.
• Write comprehensive reports, recommend application of findings, and present clear and concise oral reports of processes and accomplishments.
• Participate in writing and reviewing Standard Operating Procedures (SOPs), metabolism assay acceptance criteria, and suggest practical changes.
• Comply with SOPs, guidelines, and good housekeeping policies.
• Follow and promote company's policies, including safety policies, practices, and procedures to maintain a safe work environment.

Requirements

• PhD, Master, or Bachelor’s degree in Chemistry, Biology, or related science degree.
• At least 3+ years of related experience for PhD, 10+ years for Master’s, and 13+ years for Bachelor’s degree.
• Strong knowledge and experience of experimental methods, concepts, and techniques relevant to metabolite identification and profiling.
• Extensive experience of interpreting complex mass spectrometry data.
• Familiarity with specialized metabolic profiling software.
• A good understanding of regulatory guidance like MIST guidance and acceptance criteria in discovery and development stages.
• Emerging skills in novel experimental methods, concepts, and techniques.
• Independent thought and scientific creativity.
• Technical success and proficiency in projects.
• Ability to independently propose and conduct research and develop new methodologies to implement and resolve complex problems.
• Effective oral and written communication and interpersonal skills.
• Good time management skills to perform multiple projects within timelines.
• Ability to work in a team environment.

Qualifications

• Must be able to work in an office environment with minimal noise conditions.
• Must be able to work in a lab setting with exposure to biohazards/chemicals.
• Must be able to wear appropriate PPE.
• Must be able to work in environments with variable noise levels.
• Must be able to stand/sit/walk for long periods of time.
• Must be able to push/pull/lift 15 lbs. routinely.
• Must be able to crouch, bend, twist, and reach.
• Must have clarity of vision.
• Must be able to identify and distinguish colors.
• Must be able to perform activities with repetitive motions.
• Must be able to work in variable temperatures (high to freezing).

Skills

• Strong knowledge and experience of experimental methods, concepts, and techniques relevant to metabolite identification and profiling.
• Extensive experience of interpreting complex mass spectrometry data.
• Familiarity with specialized metabolic profiling software.
• A good understanding of regulatory guidance like MIST guidance and acceptance criteria in discovery and development stages.
• Emerging skills in novel experimental methods, concepts, and techniques.
• Independent thought and scientific creativity.
• Technical success and proficiency in projects.
• Ability to independently propose and conduct research and develop new methodologies to implement and resolve complex problems.
• Effective oral and written communication and interpersonal skills.
• Good time management skills to perform multiple projects within timelines.

Benefits

Compliance with SOPs, guidelines, and good housekeeping policies.

Pay

$100,000 to $115,000

Schedule

Full-time